INT109208

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 16
Disease Relevance 1.19
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Miox) cytoplasm (Miox)
Anatomy Link Frequency
testis 5
embryonic stem cells 2
juvenile 1
germline 1
oocytes 1
Miox (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 26 99.28 Very High Very High Very High
medulla 4 82.24 Quite High
Analgesic 2 68.80 Quite High
adenocard 14 42.96 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 98 97.88 Very High Very High Very High
Volume Depletion And Dehydration 4 96.60 Very High Very High Very High
Stress 4 87.44 High High
Repression 28 82.28 Quite High
Cancer 28 62.00 Quite High
Germ Cell And Embryonal Neoplasms 14 59.96 Quite High
Male Infertility 14 38.92 Quite Low
Seminoma 14 38.72 Quite Low
Reprotox - General 3 28 5.00 Very Low Very Low Very Low
Neurological Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX2 inhibition (COX2 inhibitor-treated or COX2-/- MMICs) dramatically reduced the expression of organic osmolyte uptake mechanisms including betaine (BGT1) and sodium-myo-inositol transporter and aldose reductase mRNA expression under hypertonic conditions.
Gene_expression (expression) of aldose reductase mRNA associated with cox2
1) Confidence 0.15 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12637551 Disease Relevance 0.33 Pain Relevance 0.56
COX2 inhibition (COX2 inhibitor-treated or COX2-/- MMICs) dramatically reduced the expression of organic osmolyte uptake mechanisms including betaine (BGT1) and sodium-myo-inositol transporter and aldose reductase mRNA expression under hypertonic conditions.
Gene_expression (expression) of aldose reductase mRNA associated with cox2
2) Confidence 0.13 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12637551 Disease Relevance 0.34 Pain Relevance 0.60
We detected robust expression of miRNAs encoded on the X chromosome in postnatal day 14 testes, consistent with prior studies showing their resistance to meiotic sex chromosome inactivation.
Gene_expression (expression) of miRNAs in testes
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
The least differentiated cells in the testis may be the source of undiscovered miRNAs just as embryonic stem cells possess miRNAs distinct from those in adult tissues [48].
Gene_expression (source) of miRNAs in embryonic stem cells
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
We found that 359 of the 465 mouse pre-miRNAs, produced reads from one or both strands during P7-P14 of testicular development.
Gene_expression (produced) of miRNAs
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
The least differentiated cells in the testis may be the source of undiscovered miRNAs just as embryonic stem cells possess miRNAs distinct from those in adult tissues [48].
Gene_expression (source) of miRNAs in embryonic stem cells
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
By contrast, more than half of the miRNAs most enriched at P14 (i.e., 449c, 34b, 34c, 743b, 471, 204, 878, 880, 883a, 743a, 881, 375, 760, 741, 470, 871, 465b-1, 465b-2, 883b, 465c-1, 465c2, 465a, 467a) were abundantly expressed (Figure 2B).
Gene_expression (expressed) of miRNAs
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
Several groups have described the complement of miRNAs present in the adult mouse testis [14], [15], [16] or human testicular tumors [10], [17], [18] using low-throughput assays and more recently Next Generation Sequencing methods [19].
Gene_expression (present) of miRNAs in testis associated with testicular cancer
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.28 Pain Relevance 0
We were able to detect several miRNAs, which showed evidence of significant internal editing (>5%) in juvenile mice.
Gene_expression (detect) of miRNAs in juvenile
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.08 Pain Relevance 0
We identified eleven putative novel pubertal testis miRNAs whose developmental expression suggests a possible role in early male germ cell development.
Gene_expression (expression) of miRNAs in testis
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
We have identified 11 putative novel testis-expressed miRNAs in addition to the miRNA variants on the X chromosome described previously [44].
Gene_expression (expressed) of miRNAs in testis
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
It is intriguing that newborn ovaries, predominantly composed of meiotic oocytes, show a similar enrichment for expression of miRNAs from chromosomes 2 and X, potentially indicating some common regulation of meiotic miRNAs in both sexes [40].
Gene_expression (expression) of miRNAs in oocytes
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
The peculiar behaviors of a large number of miRNAs expressed in the germline (i.e., resistance to meiotic sex chromosome inactivation and strong chromosomal association) argues for the need to identify additional miRNA transcriptional regulators capable of acting in cis on chromosomes 2, 12, and X.
Gene_expression (expressed) of miRNAs in germline
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
Previous studies have shown miRNAs to be abundant in the mouse testis by postnatal day 14; however, through Next Generation Sequencing of testes from a B6;129 background we found abundant earlier expression of miRNAs and describe shifts in the miRNA signature during this period.
Gene_expression (expression) of miRNAs in testis
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
By contrast, about 20% of miRNAs expressed in the adult testis switch from the strand predominant at P14 (Table S10).
Gene_expression (expressed) of miRNAs in adult testis
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.17 Pain Relevance 0
The expression and modification of miRNAs have been an area of intense interest.
Gene_expression (expression) of miRNAs
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0

General Comments

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