INT109218

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
nerve 2
neural 2
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 58 97.32 Very High Very High Very High
addiction 3 97.08 Very High Very High Very High
opiate 3 96.68 Very High Very High Very High
Pain 1 86.60 High High
Opioid 5 85.20 High High
Morphine 2 80.68 Quite High
cerebral cortex 1 79.44 Quite High
hyperexcitability 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 58 97.32 Very High Very High Very High
Opiate Addiction 3 97.08 Very High Very High Very High
Cancer 1 88.28 High High
Peripheral Neuropathy 2 87.88 High High
Drug Induced Neurotoxicity 24 25.00 Low Low
Frailty 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment with oxaliplatin, phosphorylated neurofilament heavy subunit (pNF-H) immunoreactivity was reduced in neuronal cell bodies, but unchanged in nerve fibres, of the L5 DRG.
Negative_regulation (reduced) of Phosphorylation (phosphorylated) of pNF-H in nerve associated with dorsal root ganglion
1) Confidence 0.36 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.52 Pain Relevance 0.26
This downregulation and the aberrant hyperphosphorylation of NF-H proteins might have important consequences in the development of neural plasticity associated with opiate addiction in humans.
Negative_regulation (downregulation) of Phosphorylation (hyperphosphorylation) of NF-H in neural associated with addiction and opiate
2) Confidence 0.18 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.25 Pain Relevance 0.93

General Comments

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