INT109219

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.22
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cdk5r1) nucleus (Cdk5r1) embryo development (Cdk5r1)
cell cycle (Cdk5r1) kinase activity (Cdk5r1) cytoplasm (Cdk5r1)
Anatomy Link Frequency
brain 2
neuronal 1
neurons 1
cortex 1
Cdk5r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 6 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
Opioid 20 99.84 Very High Very High Very High
addiction 12 99.60 Very High Very High Very High
opiate 12 99.40 Very High Very High Very High
Morphine 8 99.16 Very High Very High Very High
Hyperalgesia 3 99.04 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
cerebral cortex 4 97.08 Very High Very High Very High
allodynia 1 93.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 100.00 Very High Very High Very High
Nociception 1 100.00 Very High Very High Very High
Opiate Addiction 12 99.60 Very High Very High Very High
Hyperalgesia 3 99.04 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
Neuropathic Pain 1 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic morphine (10-100 mg/kg for 5 days) induced marked decreases in cdk5 (40%) and p35 (47%) in rat brain.
Negative_regulation (decreases) of p35 in brain associated with morphine
1) Confidence 0.43 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95
Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation.
Negative_regulation (Downregulation) of p35 in neuronal associated with opiate and opioid
2) Confidence 0.32 Published 2003 Journal Neuropsychopharmacology Section Title Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.71
The results suggest that opiate addiction is associated with downregulation of cdk5/p35 levels in the brain.
Negative_regulation (downregulation) of p35 in brain associated with addiction and opiate
3) Confidence 0.32 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.93
Decreased immunodensities of cdk5 (18%) and p35 (26-44%) were found in the prefrontal cortex of opioid addicts compared with matched controls.
Negative_regulation (Decreased) of p35 in cortex associated with opioid
4) Confidence 0.31 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.73
We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization.
Negative_regulation (employed) of p35 in neurons associated with nociception, pain, inflammation and dorsal horn neuron
5) Confidence 0.14 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.73 Pain Relevance 0.92

General Comments

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