INT109222

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
brain 2
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 99.70 Very High Very High Very High
cerebral cortex 1 97.68 Very High Very High Very High
Opioid 5 96.16 Very High Very High Very High
cocaine 4 95.64 Very High Very High Very High
opiate 3 75.00 Quite High
addiction 3 72.64 Quite High
Disease Link Frequency Relevance Heat
Newborn Drug Withdrawal Syndrome 1 85.68 High High
Opiate Addiction 3 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14.
Positive_regulation (induced) of Negative_regulation (decrease) of Cdk5 associated with morphine
1) Confidence 0.50 Published 2006 Journal Neurotoxicol Teratol Section Abstract Doc Link 16962740 Disease Relevance 0.09 Pain Relevance 0.44
In contrast, chronic morphine (10-100 mg/kg for 5 days) induced marked decreases in cdk5 (40%) and p35 (47%) in rat brain.
Positive_regulation (induced) of Negative_regulation (decreases) of cdk5 in brain associated with morphine
2) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.14 Pain Relevance 0.95

General Comments

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