INT10923

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 22.87
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
lipid metabolic process (Lipg)
Anatomy Link Frequency
muscles 2
soleus 2
EDL 2
central nervous system 1
microglial cell 1
Lipg (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 25 99.90 Very High Very High Very High
agonist 39 99.64 Very High Very High Very High
cva 44 99.50 Very High Very High Very High
Cannabinoid receptor 66 99.46 Very High Very High Very High
backache 4 99.32 Very High Very High Very High
Central nervous system 8 99.28 Very High Very High Very High
cytokine 68 99.04 Very High Very High Very High
Endocannabinoid 40 98.48 Very High Very High Very High
antagonist 13 95.48 Very High Very High Very High
Bile 12 94.96 High High
Disease Link Frequency Relevance Heat
Hypertrophy 69 100.00 Very High Very High Very High
Acute-phase Reaction 4 99.96 Very High Very High Very High
Pain 26 99.90 Very High Very High Very High
Apoptosis 78 99.76 Very High Very High Very High
Thrombocytopenia 34 99.72 Very High Very High Very High
Hyponatremia 3 99.60 Very High Very High Very High
Hemorrhage 21 99.50 Very High Very High Very High
Cancer 223 99.48 Very High Very High Very High
Targeted Disruption 230 99.40 Very High Very High Very High
Neutropenia 27 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to wild-type mice, cftr (-/-) mice had blunted increases in pancreatic trypsin and serum lipase activities, but similar percentages of pancreatic trypsinogen activation.
Positive_regulation (increases) of serum lipase
1) Confidence 0.50 Published 2005 Journal Gastroenterology Section Body Doc Link 16083720 Disease Relevance 0.19 Pain Relevance 0
The microspheres are contained within a macroporous cylinder which also contains a reversibly inactivated lipase.
Positive_regulation (inactivated) of lipase
2) Confidence 0.43 Published 1992 Journal J. Biomed. Mater. Res. Section Abstract Doc Link 1527096 Disease Relevance 0 Pain Relevance 0.33
It has been reported that a pancreatic lipase inhibitor, orlistat prevented obesity and hyperlipidemia through the enhancement of fat excretion in feces and the inhibition of pancreatic lipase [23].
Positive_regulation (pancreatic) of lipase in fat associated with obesity and hyperlipidemia
3) Confidence 0.30 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1097713 Disease Relevance 1.14 Pain Relevance 0
We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol.
Positive_regulation (inactivation) of lipase associated with endocannabinoid
4) Confidence 0.28 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20729846 Disease Relevance 0.07 Pain Relevance 0.65
Mean MEPP amplitudes were significantly increased in EDL and soleus but reduced in the diaphragm from affected mice.
Positive_regulation (increased) of EDL in soleus
5) Confidence 0.26 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555049 Disease Relevance 0.26 Pain Relevance 0.25
Other grade 3–4 adverse events included elevation of lipase, bilirubin, and back pain.
Positive_regulation (elevation) of lipase associated with backache
6) Confidence 0.22 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.75 Pain Relevance 0.19
After a pilot study, the following protocol was established: ablation of the GTN for 10 days to induce hypertrophy of the PLN and SOL; and in a separate group of animals ablation of the TA for 4 weeks to induce hypertrophy in the EDL.
Positive_regulation (induce) of EDL in EDL associated with hypertrophy
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.26 Pain Relevance 0
Grade 3–4 elevations in bilirubin occurred in 9% and lipase in 18% of patients.
Positive_regulation (elevations) of lipase
8) Confidence 0.16 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 1.43 Pain Relevance 0.13
The majority of serum chemistry abnormalities ranged from mild to moderate and included elevations of AST/ALT in 4% of patients and elevations of bilirubin and lipase, occurred in 9% and 14% of patients, respectively.
Positive_regulation (elevations) of lipase associated with congenital anomalies
9) Confidence 0.14 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.27 Pain Relevance 0
Twelve patients had treatment interruptions due to pain and lipase elevation.
Positive_regulation (elevation) of lipase associated with pain
10) Confidence 0.14 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.93 Pain Relevance 0.20
While CSA was increased in the mdx 11L EDL, tetanic force production was unchanged (Table 2).
Positive_regulation (increased) of EDL
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.06 Pain Relevance 0
In accord with prior studies that have found that myostatin preferentially acts on fast fiber types, the mean CSA of type IIA and IIB fibers was increased in the EDL while the mean CSA of only type IIA fibers was increased in the soleus (Figs. 5A, B and 6A, B).
Positive_regulation (increased) of EDL in soleus
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.33 Pain Relevance 0
The initial acute phase reaction (increase of serum amylase and lipase (figure 3a and 3b) and cytokines MCP-1 and IL-6 (table 1) was similar in R122H mice and controls.
Positive_regulation (increase) of lipase associated with acute-phase reaction and cytokine
13) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 1.15 Pain Relevance 0.12
The patient's lipase and amylase levels were also elevated, but an abdominal ultrasound was normal.
Positive_regulation (elevated) of lipase
14) Confidence 0.13 Published 2003 Journal Pharmacotherapy Section Abstract Doc Link 12921254 Disease Relevance 0.84 Pain Relevance 0.09
Compared to controls, lipase (after 24 hours) and amylase (after 48 hours), but not IL-6 and MCP-1 levels were significantly elevated in R122H animals (table 1).
Positive_regulation (elevated) of lipase
15) Confidence 0.13 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.73 Pain Relevance 0.09
R122H mice showed elevated pancreatic lipase, but there was no spontaneous development of pancreatitis within 18 months.
Positive_regulation (elevated) of lipase associated with pancreatitis
16) Confidence 0.13 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1637108 Disease Relevance 0.93 Pain Relevance 0.08
However, at an age of 8 months transgenic mice displayed significantly elevated levels of serum lipase, but not of amylase (figure 2a and 2b).


Positive_regulation (elevated) of lipase associated with targeted disruption
17) Confidence 0.11 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.44 Pain Relevance 0.07
The absolute strength of the EDL was slightly increased in the mdx 11H group, yet the specific force declined by 21%.
Positive_regulation (increased) of EDL
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.06 Pain Relevance 0
Mean MEPP amplitudes were significantly increased in EDL and soleus but reduced in the diaphragm from affected mice.
Positive_regulation (increased) of EDL in EDL
19) Confidence 0.09 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555049 Disease Relevance 0.26 Pain Relevance 0.25
The stimulation of P2X7 receptors elicits a pronounced increase in the secretion of the endocannabinoid, 2-arachydonoylglycerate (2-AG) in primary microglial cell cultures by the activation of diacylglycerol lipase and the simultaneous inhibition of monoacylycerol lipase, the enzyme responsible for endocannabinoid degradation [72].
Positive_regulation (activation) of lipase in microglial cell associated with endocannabinoid
20) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.18 Pain Relevance 0.26

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