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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) endoplasmic reticulum (Calcrl)
plasma membrane (Calcrl) lysosome (Calcrl) signal transducer activity (Calcrl)
Anatomy Link Frequency
uterine 2
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 2 95.28 Very High Very High Very High
calcitonin gene related peptide 1 92.32 High High
Nucleus accumbens 4 86.80 High High
Inflammation 5 62.64 Quite High
qutenza 2 50.00 Quite Low
Pain 2 35.36 Quite Low
cytokine 1 22.88 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 72 98.56 Very High Very High Very High
Cancer 22 86.88 High High
Apoptosis 9 81.88 Quite High
INFLAMMATION 3 62.64 Quite High
Pressure And Volume Under Development 2 50.00 Quite Low
Rheumatoid Arthritis 23 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Endometriosis (extended) 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRLR expression in mesenteric resistance arteries was upregulated in CAP-HS and CON-HS compared with CON-NS rats, but RAMP1 content was not different among these groups.
Positive_regulation (upregulated) of Gene_expression (expression) of CRLR
1) Confidence 0.67 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0 Pain Relevance 0
Coexpression of RAMP1 and CRLR resulted in functional CGRP1 receptors; the complex of RAMP2 or RAMP3 and CRLR created functional adrenomedullin receptor.
Positive_regulation (resulted) of Gene_expression (Coexpression) of CRLR
2) Confidence 0.48 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.06 Pain Relevance 0.26
Using a rat uterine fibroid-derived cell line (ELT3), Thota and Yallampalli [34] demonstrated that expression of CALCRL and RAMP1 increased with progesterone and decreased with estrogen, consistent with what Helvering et al found in the array work (Table 3).
Positive_regulation (increased) of Gene_expression (expression) of CALCRL in uterine associated with uterine fibroids
3) Confidence 0.24 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.83 Pain Relevance 0.05

General Comments

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