INT109246

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 4.71
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) endoplasmic reticulum (Calcrl)
plasma membrane (Calcrl) lysosome (Calcrl) signal transducer activity (Calcrl)
Anatomy Link Frequency
nucleus accumbens 2
placenta 2
bar 1
macrophages 1
smooth muscle 1
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 193 100.00 Very High Very High Very High
b2 receptor 10 100.00 Very High Very High Very High
dorsal root ganglion 107 99.80 Very High Very High Very High
Spinal cord 6 99.72 Very High Very High Very High
Nucleus accumbens 12 99.68 Very High Very High Very High
Inflammation 131 98.52 Very High Very High Very High
antagonist 128 97.12 Very High Very High Very High
calcitonin gene related peptide 4 92.32 High High
Sciatic nerve 1 89.64 High High
Thermal hyperalgesia 3 88.20 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 112 99.80 Very High Very High Very High
Cancer 154 99.68 Very High Very High Very High
Uterine Fibroids 288 98.56 Very High Very High Very High
INFLAMMATION 129 98.52 Very High Very High Very High
Neuroma 3 98.00 Very High Very High Very High
Leukemia 7 91.72 High High
Hyperalgesia 9 88.20 High High
Immunization 4 87.12 High High
Neuropathic Pain 6 82.04 Quite High
Apoptosis 39 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRLR and RAMP1 are expressed abundantly in cells of the amygdaloid complex, including the central nucleus [9], indicating the presence of functional CGRP1 receptors.
Gene_expression (expressed) of CRLR in nucleus
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.05 Pain Relevance 0.55
CGRP receptor markers (CRLR and RAMP1) were expressed in invading macrophages.
Gene_expression (expressed) of CRLR in macrophages associated with calcitonin gene-related peptide
2) Confidence 0.75 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.84 Pain Relevance 1.35
Expression of components of the CGRP receptor, calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1), was determined by the use of Western blot analysis.
Spec (determined) Gene_expression (Expression) of calcitonin receptor-like receptor
3) Confidence 0.75 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0.07 Pain Relevance 0
Expression of components of the CGRP receptor, calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1), was determined by the use of Western blot analysis.
Spec (determined) Gene_expression (Expression) of CRLR
4) Confidence 0.75 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0.07 Pain Relevance 0
CRLR expression in mesenteric resistance arteries was upregulated in CAP-HS and CON-HS compared with CON-NS rats, but RAMP1 content was not different among these groups.
Gene_expression (expression) of CRLR
5) Confidence 0.75 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0 Pain Relevance 0
Expression of components of the CGRP receptor, calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1), was determined by the use of Western blot analysis.
Spec (determined) Gene_expression (Expression) of CGRP receptor
6) Confidence 0.75 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0.07 Pain Relevance 0
In the present study, we used real-time quantitative RT-PCR to detect and quantitate the relative expression of CGRP, CRLR, RAMP1-3 and RDC-1 in the nucleus accumbens of intact rats and rats with inflammation.
Gene_expression (expression) of CRLR in nucleus accumbens associated with nucleus accumbens and inflammation
7) Confidence 0.74 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.18 Pain Relevance 0.44
Coexpression of RAMP1 and CRLR resulted in functional CGRP1 receptors; the complex of RAMP2 or RAMP3 and CRLR created functional adrenomedullin receptor.
Gene_expression (Coexpression) of CRLR
8) Confidence 0.74 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.06 Pain Relevance 0.26
Our results demonstrate that CGRP, CRLR, RAMP1 and RAMP2 exist in the nucleus accumbens of intact rats, and that they were significantly upregulated in rats with inflammation.
Gene_expression (exist) of CRLR in nucleus accumbens associated with nucleus accumbens and inflammation
9) Confidence 0.64 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.19 Pain Relevance 0.47
Gene expression of CGRP and the CGRP-receptor components, receptor activity-modifying protein 1, receptor component protein and calcitonin receptor-like receptor was measured by quantitative RT-PCR.
Gene_expression (expression) of calcitonin receptor-like receptor associated with calcitonin gene-related peptide
10) Confidence 0.46 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19864020 Disease Relevance 0.30 Pain Relevance 0.75
Expression of calcitonin receptor-like receptor (CALCRL) was inhibited by estrogen in the rat uterus [34] and placenta [35].
Gene_expression (Expression) of CALCRL in placenta
11) Confidence 0.36 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.15 Pain Relevance 0
Expression of calcitonin receptor-like receptor (CALCRL) was inhibited by estrogen in the rat uterus [34] and placenta [35].
Gene_expression (Expression) of calcitonin receptor-like receptor in placenta
12) Confidence 0.36 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.15 Pain Relevance 0
During pregnancy, the expression of RAMP-3 is strongly increased whereas RAMP-2 and CLR expression are depressed.
Gene_expression (expression) of CLR
13) Confidence 0.35 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09
Down-regulation of CALCRL expression in the tumor and in response to estrogen may implicate two important aspects of the tumor growth, that is, cell proliferation and angiogenesis.
Gene_expression (expression) of CALCRL associated with cancer
14) Confidence 0.32 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.69 Pain Relevance 0.04
Using a rat uterine fibroid-derived cell line (ELT3), Thota and Yallampalli [34] demonstrated that expression of CALCRL and RAMP1 increased with progesterone and decreased with estrogen, consistent with what Helvering et al found in the array work (Table 3).
Gene_expression (expression) of CALCRL in uterine associated with uterine fibroids
15) Confidence 0.32 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.82 Pain Relevance 0.05
The mRNAs coding for RAMP-1 and -3 are detected in the anterior and intermediate lobes (631) and, during lactation, the expression of RAMP-3 doubles whereas levels of CLR and RAMP-1 do not change (631).
Gene_expression (levels) of CLR in lobes
16) Confidence 0.30 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.04
A calcitonin-like substance is also expressed in the chicken pituitary, although there it colocalises with PRL, but, as in the rat, its level fluctuates inversely with PRL mRNA level (251).
Gene_expression (expressed) of calcitonin-like in pituitary
17) Confidence 0.27 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.09 Pain Relevance 0
Thus, in contrast with NK1 receptor expression, FLS cells from normal knee joints caused a significant up-regulation of the proportion of DRG neurones exhibiting B2 receptor-like labelling (Figure 4c, second bar).
Gene_expression (exhibiting) of receptor-like in bar associated with dorsal root ganglion and b2 receptor
18) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.96 Pain Relevance 0.79
The CGRP1 receptor component calcitonin-related-like receptor was expressed by periarterial nerves and smooth muscle cells, whereas receptor activity-modifying protein 1 was observed primarily on the smooth muscle.
Gene_expression (expressed) of CGRP1 receptor in smooth muscle
19) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18055875 Disease Relevance 0 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox