INT109248

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 2.45
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ramp1) signal transduction (Ramp1) transport (Ramp1)
extracellular space (Ramp1) plasma membrane (Ramp1)
Anatomy Link Frequency
nucleus accumbens 2
macrophages 1
spinal cord 1
nucleus 1
uterine 1
Ramp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 261 99.98 Very High Very High Very High
Nucleus accumbens 12 99.68 Very High Very High Very High
Calcitonin gene-related peptide 352 99.44 Very High Very High Very High
Spinal cord 15 99.36 Very High Very High Very High
Inflammation 46 98.28 Very High Very High Very High
antagonist 59 97.12 Very High Very High Very High
calcitonin gene related peptide 1 92.32 High High
Sciatic nerve 1 89.28 High High
Thermal hyperalgesia 2 87.84 High High
Neuropathic pain 6 81.68 Quite High
Disease Link Frequency Relevance Heat
Uterine Fibroids 72 98.56 Very High Very High Very High
INFLAMMATION 41 98.28 Very High Very High Very High
Neuroma 3 97.64 Very High Very High Very High
Nociception 12 93.12 High High
Hyperalgesia 5 87.84 High High
Cancer 44 86.08 High High
Apoptosis 10 81.88 Quite High
Neuropathic Pain 12 81.68 Quite High
Pressure And Volume Under Development 4 76.96 Quite High
Diabetic Nephropathy 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we used real-time quantitative RT-PCR to detect and quantitate the relative expression of CGRP, CRLR, RAMP1-3 and RDC-1 in the nucleus accumbens of intact rats and rats with inflammation.
Gene_expression (expression) of RAMP1-3 in nucleus accumbens associated with nucleus accumbens and inflammation
1) Confidence 0.72 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.18 Pain Relevance 0.45
Coexpression of RAMP1 and CRLR resulted in functional CGRP1 receptors; the complex of RAMP2 or RAMP3 and CRLR created functional adrenomedullin receptor.
Gene_expression (Coexpression) of RAMP1
2) Confidence 0.72 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.06 Pain Relevance 0.26
CGRP receptor markers (CRLR and RAMP1) were expressed in invading macrophages.
Gene_expression (expressed) of RAMP1 in macrophages associated with calcitonin gene-related peptide
3) Confidence 0.64 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.84 Pain Relevance 1.35
Our results demonstrate that CGRP, CRLR, RAMP1 and RAMP2 exist in the nucleus accumbens of intact rats, and that they were significantly upregulated in rats with inflammation.
Gene_expression (exist) of RAMP1 in nucleus accumbens associated with nucleus accumbens and inflammation
4) Confidence 0.63 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.19 Pain Relevance 0.47
Expression of components of the CGRP receptor, calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1), was determined by the use of Western blot analysis.
Spec (determined) Gene_expression (Expression) of RAMP1
5) Confidence 0.62 Published 2003 Journal J. Hypertens. Section Body Doc Link 12640252 Disease Relevance 0.07 Pain Relevance 0
CRLR and RAMP1 are expressed abundantly in cells of the amygdaloid complex, including the central nucleus [9], indicating the presence of functional CGRP1 receptors.
Gene_expression (expressed) of RAMP1 in nucleus
6) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.05 Pain Relevance 0.55
Overexpression of RAMP1 enhanced the pronociceptive effects of CGRP in the spinal cord [42].
Gene_expression (Overexpression) of RAMP1 in spinal cord associated with spinal cord and calcitonin gene-related peptide
7) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.06 Pain Relevance 0.58
In the amygdala, the BLA contains relatively more RAMP2 than RAMP1 whereas in the CeA RAMP1 expression is highest [9], consistent with the presence of CGRP1 receptors.
Gene_expression (expression) of RAMP1 in amygdala associated with amygdala
8) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.09 Pain Relevance 0.60
Western blot showed that expression of receptor activity-modifying protein 1, a subunit of the CGRP receptor, in mesenteric arteries was greater in HS-treated compared with NS-treated rats.
Gene_expression (expression) of activity-modifying protein 1 associated with calcitonin gene-related peptide
9) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17308041 Disease Relevance 0.08 Pain Relevance 0.36
Using a rat uterine fibroid-derived cell line (ELT3), Thota and Yallampalli [34] demonstrated that expression of CALCRL and RAMP1 increased with progesterone and decreased with estrogen, consistent with what Helvering et al found in the array work (Table 3).
Gene_expression (expression) of RAMP1 in uterine associated with uterine fibroids
10) Confidence 0.28 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.82 Pain Relevance 0.05
The mRNAs coding for RAMP-1 and -3 are detected in the anterior and intermediate lobes (631) and, during lactation, the expression of RAMP-3 doubles whereas levels of CLR and RAMP-1 do not change (631).
Gene_expression (levels) of RAMP-1 in lobes
11) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.04

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