INT109264

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.73
Pain Relevance 14.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
caudate-putamen 20
nucleus accumbens 4
piriform cortex 4
olfactory tubercle 4
substantia nigra 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 34 100.00 Very High Very High Very High
Substantia nigra 23 100.00 Very High Very High Very High
Ventral tegmentum 17 100.00 Very High Very High Very High
midbrain 21 99.84 Very High Very High Very High
Dopamine 152 99.04 Very High Very High Very High
withdrawal 96 98.20 Very High Very High Very High
Cannabinoid 176 97.98 Very High Very High Very High
Serotonin 22 96.00 Very High Very High Very High
Eae 16 79.04 Quite High
monoamine 5 75.92 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 94.68 High High
Syndrome 17 83.04 Quite High
Opiate Addiction 16 82.32 Quite High
Hypoxia 4 81.00 Quite High
Cognitive Disorder 9 78.84 Quite High
Attention Deficit Hyperactivity Disorder 163 77.64 Quite High
Hypothermia 16 77.16 Quite High
Drug Dependence 1 15.44 Low Low
Ocular Toxicity (including Many Sub-types) 11 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
1) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
2) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
3) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
4) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in nucleus accumbens Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
5) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in olfactory tubercle Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
6) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in piriform cortex Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
7) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in piriform cortex Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
8) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in nucleus accumbens Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
9) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in olfactory tubercle Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
10) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in olfactory tubercle Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
11) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in olfactory tubercle Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
12) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in nucleus accumbens Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
13) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in piriform cortex Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
14) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in nucleus accumbens Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
15) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of in piriform cortex Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
16) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.24 Pain Relevance 0.87
Tyrosine hydroxylase mRNA levels were increased in VTA and substantia nigra of perinatally asphyxiated rats suggesting increased dopamine synthesis consistent with increased turnover.
Positive_regulation (increased) of Transcription (levels) of Tyrosine hydroxylase in substantia nigra associated with dopamine, substantia nigra and midbrain
17) Confidence 0.04 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.98 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox