INT109265

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.50
Pain Relevance 8.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
nucleus accumbens 2
caudate-putamen 2
piriform cortex 2
olfactory tubercle 2
substantia nigra 1
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 33 100.00 Very High Very High Very High
Ventral tegmentum 9 99.68 Very High Very High Very High
COX-2 inhibitor 22 99.48 Very High Very High Very High
midbrain 39 99.24 Very High Very High Very High
Dopamine 201 99.04 Very High Very High Very High
Substantia nigra 20 98.92 Very High Very High Very High
withdrawal 48 98.20 Very High Very High Very High
Cannabinoid 88 97.98 Very High Very High Very High
Serotonin 22 96.00 Very High Very High Very High
Nucleus accumbens 31 93.64 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 217 99.48 Very High Very High Very High
Cv Unclassified Under Development 2 94.68 High High
Targeted Disruption 36 88.64 High High
Neuroblastoma 46 83.68 Quite High
Decapitation 2 83.68 Quite High
Opiate Addiction 8 82.32 Quite High
Hypoxia 4 81.00 Quite High
Cognitive Disorder 10 78.84 Quite High
Attention Deficit Hyperactivity Disorder 171 77.64 Quite High
Hypothermia 8 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
1) Confidence 0.68 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
2) Confidence 0.68 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Transcription (levels) of TH associated with parkinson's disease
3) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.69 Pain Relevance 0.16
From the COX-2 inhibitor study (Fig. 5C &5D), the number of TH-positive neurons was strongly positively correlated with the number of Nissl-stained neurons and the amount of the COX-2 inhibitor administered per day (rs ?
Transcription (number) of TH in neurons associated with cox-2 inhibitor
4) Confidence 0.38 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.28 Pain Relevance 0.13
The number of TH positive cells was counted in the contralateral and ipsilateral hemispheres at the level of third cranial nerve, within a 100??
Transcription (level) of TH in cranial nerve
5) Confidence 0.35 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.07 Pain Relevance 0.06
cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production.
Transcription (expressed) of tyrosine hydroxylase associated with neurotransmitter
6) Confidence 0.25 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.09
cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production.
Transcription (expressed) of TH associated with neurotransmitter
7) Confidence 0.25 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.09
based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH).


Transcription (expression) of TH associated with neurotransmitter
8) Confidence 0.25 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.22 Pain Relevance 0.08
based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH).


Transcription (expression) of tyrosine hydroxylase associated with neurotransmitter
9) Confidence 0.25 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.22 Pain Relevance 0.08
The level of TH mRNAs in the N2a-R?
Transcription (level) of TH
10) Confidence 0.25 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.12
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of TH in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
11) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of tyrosine hydroxylase in olfactory tubercle associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
12) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of tyrosine hydroxylase in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
13) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of TH in olfactory tubercle associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
14) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of tyrosine hydroxylase in piriform cortex associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
15) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Transcription (levels) of TH in piriform cortex associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
16) Confidence 0.23 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.22 Pain Relevance 0.83
Expression of preprotachykinin, prodynorphin, prosomatostatin, preproenkephalin and tyrosine hydroxylase mRNA was also measured [39], [47].
Transcription (Expression) of tyrosine hydroxylase
17) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.08 Pain Relevance 0.14
Tyrosine hydroxylase mRNA levels were increased in VTA and substantia nigra of perinatally asphyxiated rats suggesting increased dopamine synthesis consistent with increased turnover.
Transcription (levels) of Tyrosine hydroxylase in substantia nigra associated with dopamine, substantia nigra and midbrain
18) Confidence 0.05 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.98 Pain Relevance 0.64

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