INT109266

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.50
Pain Relevance 6.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
caudate-putamen 10
nucleus accumbens 2
piriform cortex 2
olfactory tubercle 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 8 99.68 Very High Very High Very High
withdrawal 48 98.52 Very High Very High Very High
Cannabinoid 88 98.30 Very High Very High Very High
Substantia nigra 8 97.84 Very High Very High Very High
Dopamine 21 95.36 Very High Very High Very High
Nucleus accumbens 8 93.64 High High
Eae 9 79.68 Quite High
tolerance 16 75.84 Quite High
Inflammation 42 50.00 Quite Low
Enkephalin 16 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 108 99.82 Very High Very High Very High
Opiate Addiction 8 82.96 Quite High
Hypothermia 8 77.80 Quite High
Syndrome 8 64.40 Quite High
INFLAMMATION 52 50.00 Quite Low
Aging 18 40.88 Quite Low
Disease 35 8.16 Low Low
Toxicity 15 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 10 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
1) Confidence 0.42 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
2) Confidence 0.42 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Negative_regulation (loss) of Transcription (levels) of TH associated with parkinson's disease
3) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in olfactory tubercle Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
4) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in piriform cortex Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
5) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in nucleus accumbens Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
6) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in olfactory tubercle Transcription (levels) of tyrosine hydroxylase in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
7) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in nucleus accumbens Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
8) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Negative_regulation (decreased) of in piriform cortex Transcription (levels) of TH in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
9) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.84

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