INT109272

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
brain 2
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 91 100.00 Very High Very High Very High
positron emission tomography 46 97.90 Very High Very High Very High
Neurotransmitter 5 91.68 High High
drug abuse 2 85.52 High High
Glutamate 1 78.56 Quite High
Morphine 1 54.24 Quite High
Clonidine 1 52.56 Quite High
Cholecystokinin 1 51.44 Quite High
Antiemetics 2 25.00 Low Low
imagery 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 4 97.68 Very High Very High Very High
Impulse Control Disorders 3 90.52 High High
Alcohol Addiction 1 86.52 High High
Drug Dependence 3 85.52 High High
Attention Deficit Hyperactivity Disorder 80 65.28 Quite High
Brain Disease 1 59.56 Quite High
Disease 67 50.00 Quite Low
Nerve Degeneration 7 35.52 Quite Low
Parkinsonian Disorders 39 5.00 Very Low Very Low Very Low
Congenital Anomalies 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not in any known regulatory region, and although the A1 allele is associated with a decrease in dopamine D2 binding and glucose metabolic rates in many brain regions [83,89,90], its mechanism for influencing DRD2 expression is unknown.
Negative_regulation (decrease) of dopamine D2 Binding (binding) of in brain associated with dopamine
1) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.46 Pain Relevance 0.32
This type of PET study is based on the ability of endogenous dopamine (released by the administration of amphetamine) to compete with the binding of [11C]-raclopride to D2R (Laruelle 2000).
Negative_regulation (compete) of D2R Binding (binding) of associated with dopamine and positron emission tomography
2) Confidence 0.34 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.06 Pain Relevance 0.66
AS-9705 inhibited [3H]spiperone binding to human dopamine D2.long receptors, and [3H]R(+)-7-OH-DPAT binding to human dopamine D3 receptors (IC50 values of 58.5 +/- 14.0 and 60.8 +/- 7.8 (nmol/l), respectively) and had negligible affinity (IC50 > 10 mumol/l) for other neurotransmitter recognition sites examined.
Negative_regulation (inhibited) of dopamine D2 Spec (examined) Binding (binding) of associated with neurotransmitter and dopamine
3) Confidence 0.21 Published 2003 Journal Arzneimittelforschung Section Abstract Doc Link 12642965 Disease Relevance 0.25 Pain Relevance 0.28

General Comments

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