INT109279

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 14
Total Number 19
Disease Relevance 4.06
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 6
neurons 4
NAc 2
brain 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 48 100.00 Very High Very High Very High
Inflammation 38 99.92 Very High Very High Very High
Pain 35 99.92 Very High Very High Very High
Hippocampus 91 99.84 Very High Very High Very High
Dopamine 199 99.64 Very High Very High Very High
opiate 12 99.36 Very High Very High Very High
Analgesic 8 99.32 Very High Very High Very High
addiction 25 99.02 Very High Very High Very High
Opioid 10 98.80 Very High Very High Very High
Nucleus accumbens 5 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 210 100.00 Very High Very High Very High
INFLAMMATION 39 99.44 Very High Very High Very High
Morphine Dependence 6 98.96 Very High Very High Very High
Nociception 11 98.92 Very High Very High Very High
Weight Loss 2 98.56 Very High Very High Very High
Pain 34 91.24 High High
Targeted Disruption 122 89.52 High High
Weight Gain 4 67.64 Quite High
Hyperalgesia 34 66.88 Quite High
Body Weight 20 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm.
Regulation (changes) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with analgesic and hippocampus
1) Confidence 0.62 Published 2003 Journal Cell Res. Section Title Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.90
The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence.
Spec (possible) Regulation (regulation) of Phosphorylation (phosphorylation) of CREB associated with addiction and morphine
2) Confidence 0.61 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.25 Pain Relevance 0.93
Moreover, we studied the effects of OMF and morphine on CREB phosphorylation and colocalization of phosphorylated CREB (P-CREB) with CaMKIV in cultured rat hippocampal neurons by Western blot, and confocal fluorescence microscopy analyses.
Spec (analyses) Regulation (effects) of Phosphorylation (phosphorylation) of CREB in neurons associated with morphine
3) Confidence 0.61 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.65
Reflecting the changes in phosphorylation of CREB, ROS augmented PGC-1?
Regulation (changes) of Phosphorylation (phosphorylation) of CREB
4) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.11 Pain Relevance 0
Consequently, the 90% reduction of CREB in CREBalphaDelta mutant mice differentially affects CREB phosphorylation and induction of downstream targets of CREB in the NAc and VTA.
Regulation (affects) of Phosphorylation (phosphorylation) of CREB in NAc associated with ventral tegmentum and nucleus accumbens
5) Confidence 0.45 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.70
The present study was designed to determine the changes of phosphorylation of cAMP- response element binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204) in conditioned place preference (CPP) paradigm.
Spec (determine) Regulation (changes) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
6) Confidence 0.45 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.33
They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels.
Neg (without) Regulation (affecting) of Phosphorylation (phosphorylation) of CREB
7) Confidence 0.45 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.65
CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.
Regulation (regulated) of Phosphorylation (phosphorylation) of CREB associated with addiction and morphine
8) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.27 Pain Relevance 1.11
Each brain region tested showed a tendency for elevated CREB phosphorylation after chronic stress which reflected the increase in luciferase activity.
Regulation (tendency) of Phosphorylation (phosphorylation) of CREB in brain associated with stress
9) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.13
To better understand the role of CREB in opioids dependence and underlying signal pathways, we compared the effects of three ohmfentanyl stereoisomers ((-)-cis-(3R,4S,2'R) OMF (F9202), (+)-cis-(3R,4S,2'S) OMF (F9204), (-)-cis-(3S,4S,2'R) OMF (F9203)) and morphine on CREB phosphorylation and the expression of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in hippocampus derived from mice which displayed conditioned place preference (CPP) behavior by Western blot, and immunohistochemistry analyses.
Regulation (effects) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with addiction, hippocampus, opioid and morphine
10) Confidence 0.44 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.60
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.
Regulation (impact) of Phosphorylation (phosphorylation) of CREB associated with nociception and inflammation
11) Confidence 0.44 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17692820 Disease Relevance 0.71 Pain Relevance 0.50
These findings suggest that alterations in the phosphorylation of CREB be relevant to opiates signaling and the development of opiates dependence.
Regulation (alterations) of Phosphorylation (phosphorylation) of CREB associated with addiction and opiate
12) Confidence 0.27 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.96
To examine whether imipramine also has an effect on the stress-induced phosphorylation of CREB we determined CREB phosphorylation in mice subjected to chronic stress plus imipramine treatment.
Spec (whether) Regulation (effect) of Phosphorylation (phosphorylation) of CREB associated with stress
13) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.73 Pain Relevance 0.07
As one important endocrine stress response is the activation of the adrenergic system[4], most likely the protein kinase A predominantly is involved in stress-induced CREB phosphorylation.
Regulation (involved) of Phosphorylation (phosphorylation) of CREB associated with stress
14) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.74 Pain Relevance 0.17
In addition, the NO signaling pathway can mediate the expression of CREB target genes by controlling CREB-DNA binding, which is independent of CREB phosphorylation [62].
Neg (independent) Regulation (independent) of Phosphorylation (phosphorylation) of CREB
15) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.30 Pain Relevance 0.16
Moreover, we studied the effects of OMF and morphine on CREB phosphorylation and colocalization of phosphorylated CREB (P-CREB) with CaMKIV in cultured rat hippocampal neurons by Western blot, and confocal fluorescence microscopy analyses.
Spec (analyses) Regulation (effects) of Phosphorylation (phosphorylated) of CREB in neurons associated with morphine
16) Confidence 0.23 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.66
Furthermore, we performed an analysis of intracellular signaling mechanisms that could mediate the actions of 3-MT on hTAAR1 expressed in HEK cells. 3-MT caused a rapid and prolonged phosphorylation of Erk2 and CREB only in cells expressing hTAAR1 (Figure 2B,C) thus indicating that a Gs-dependent signaling cascade involving accumulation of cAMP and activation of Erk2 and CREB is likely involved in the action of TAAR1.


Regulation (prolonged) of Phosphorylation (phosphorylation) of CREB
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.08 Pain Relevance 0.11
In the Thr to Ala mutant mouse [36], in which Thr75 cannot be phosphorylated, increasing dopamine levels no longer affect downstream processes such as CREB phosphorylation.
Regulation (affect) of Phosphorylation (phosphorylation) of CREB associated with dopamine
18) Confidence 0.20 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.19
Likewise, there was no change in basal CREB phosphorylation.
Neg (no) Regulation (change) of Phosphorylation (phosphorylation) of CREB
19) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.15 Pain Relevance 0.12

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