INT109280

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 11.81
Pain Relevance 10.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
liver 8
hippocampus 8
striatum 3
dorsal 2
neurons 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 118 100.00 Very High Very High Very High
fluoxetine 64 100.00 Very High Very High Very High
Morphine 47 100.00 Very High Very High Very High
ketamine 7 99.86 Very High Very High Very High
Hippocampus 165 99.44 Very High Very High Very High
narcan 4 98.50 Very High Very High Very High
Spinal cord 28 98.48 Very High Very High Very High
antidepressant 364 98.06 Very High Very High Very High
depression 194 97.96 Very High Very High Very High
antagonist 41 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 404 99.98 Very High Very High Very High
Targeted Disruption 181 99.98 Very High Very High Very High
Urological Neuroanatomy 9 99.84 Very High Very High Very High
Anxiety Disorder 19 99.80 Very High Very High Very High
Insulin Resistance 168 99.60 Very High Very High Very High
Death 6 99.32 Very High Very High Very High
Depression 238 98.68 Very High Very High Very High
Alzheimer's Dementia 40 98.54 Very High Very High Very High
Neuroblastoma 3 97.68 Very High Very High Very High
Neurodegenerative Disease 73 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.
Negative_regulation (suppress) of Phosphorylation (phosphorylation) of CREB associated with ketamine and morphine
1) Confidence 0.59 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.94
Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with narcan, hippocampus and morphine
2) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19289113 Disease Relevance 0.21 Pain Relevance 0.94
When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus and morphine
3) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.24 Pain Relevance 1.16
Also variable unpredictable stress (footshock, cold, restraint) decreased phosphorylation of CREB in frontal cortex, hippocampus and striatum[37].
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with stress, urological neuroanatomy and hippocampus
4) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.87 Pain Relevance 0.32
KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of CREB associated with morphine
5) Confidence 0.58 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.74
This mutation blocks the phosphorylation of CREB.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of CREB
6) Confidence 0.57 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.09 Pain Relevance 0.03
Blockade of hippocampal CREB phosphorylation by microinjection of H89 (5.19 microg/1.0 microl), a PKA (protein kinase A) inhibitor, abolished the anxiolytic-like effects of 7-NI (i.p., 30 mg/kg/d for 21 d).
Negative_regulation (Blockade) of Phosphorylation (phosphorylation) of CREB associated with anxiety disorder
7) Confidence 0.51 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.59 Pain Relevance 0.24
expression, elicited by reduced ROS levels in the liver, is accompanied by decreased phosphorylation of CREB in db/db mice.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of CREB in liver
8) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.05 Pain Relevance 0
associated with reduction of ROS in liver is accompanied by reduced phosphorylation of CREB.


Negative_regulation (reduced) of Phosphorylation (phosphorylation) of CREB in liver
9) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
Thus, reduction of ROS in liver might reduce the gene expression of IRS-2 by attenuating CREB phosphorylation.
Negative_regulation (attenuating) of Phosphorylation (phosphorylation) of CREB in liver
10) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.12 Pain Relevance 0
In line with the luciferase data, treatment with imipramine during chronic social stress reduced CREB phosphorylation to control levels.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of CREB associated with stress
11) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.80 Pain Relevance 0.03
Treatment of the stressed mice with the antidepressant imipramine normalized luciferase expression to control levels in all brain regions and likewise reduced CREB-phosphorylation.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of CREB in brain associated with antidepressant
12) Confidence 0.43 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.69 Pain Relevance 0.25
KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of CREB associated with morphine
13) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.75
The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered.
Negative_regulation (reached) of Phosphorylation (phosphorylation) of CREB in neurons associated with morphine
14) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.73
In contrast, phosphorylated CREB (the active form of this transcription factor) was reduced in cortex and/or striatum (23-26%) of mu- and delta-KO mice, but not in kappa-KO animals.
Neg (not) Negative_regulation (reduced) of Phosphorylation (phosphorylated) of CREB in striatum
15) Confidence 0.40 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.18 Pain Relevance 0.92
Blockade of hippocampal CREB phosphorylation by microinjection of H89 (5.19 microg/1.0 microl), a PKA (protein kinase A) inhibitor, abolished the anxiolytic-like effects of 7-NI (i.p., 30 mg/kg/d for 21 d).
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of CREB associated with anxiety disorder
16) Confidence 0.38 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.59 Pain Relevance 0.22
Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of CREB associated with targeted disruption and fluoxetine
17) Confidence 0.36 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.38 Pain Relevance 0.59
Our results here show that targeted mutation of EphB1 receptor can prevent development of LTP and the associated phosphorylation of CaMKII and ERK and CREB and expression of c-Fos in the mouse SC.
Negative_regulation (prevent) of Phosphorylation (phosphorylation) of CREB associated with long-term potentiation and spinal cord
18) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.28 Pain Relevance 0.77
Overexpression of SOD1 reduces phosphorylation of CREB.
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of CREB
19) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.10 Pain Relevance 0.03
The inhibition of hepatic insulin resistance was accompanied by attenuation of phosphorylation of cAMP-responsive element-binding protein (CREB), which is a main regulator of PGC-1?
Negative_regulation (attenuation) of Phosphorylation (phosphorylation) of CREB associated with insulin resistance
20) Confidence 0.33 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494675 Disease Relevance 0.62 Pain Relevance 0

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