INT109301

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.45
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
neuronal 2
liver 2
granulosa cells 2
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.88 Very High Very High Very High
withdrawal 3 94.40 High High
opioid receptor 2 92.40 High High
agonist 2 85.76 High High
antagonist 1 81.76 Quite High
narcan 1 80.48 Quite High
cytokine 4 76.56 Quite High
Morphine 1 73.04 Quite High
Enkephalin 1 69.88 Quite High
mu opioid receptor 1 60.36 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.60 Very High Very High Very High
Apoptosis 5 92.60 High High
Frailty 2 91.32 High High
Hypertrophy 16 82.36 Quite High
Toxicity 2 77.52 Quite High
Hepatotoxicity 3 76.80 Quite High
Cancer 6 75.00 Quite High
Necrosis 4 75.00 Quite High
Insulin Resistance 26 67.16 Quite High
Targeted Disruption 24 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, MES promoted the tyrosine phosphorylation of YXXM motif in IRS protein (IRS-1 and IRS-2) (Fig. 8F; pYXXM) that leads to the activation of PI3K and Akt phosphorylation in the liver [37].
Positive_regulation (activation) of Phosphorylation (phosphorylation) of PI3K in liver
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.14 Pain Relevance 0
At the membrane, PI3K phosphorylates PI(4,5)P2 at the D3 position on the inositol ring producing PI(3,4,5)P3 [16], an important second messenger required for the oncogenic [17] and growth factor [18] induced activation of mTORC1.
Positive_regulation (activation) of Phosphorylation (phosphorylates) of PI3K
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0
DAMGO also stimulated Akt phosphorylation via PI 3-K in this primary neuronal culture.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PI 3-K in neuronal
3) Confidence 0.27 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12646285 Disease Relevance 0.40 Pain Relevance 0.53
Acetaminophen also increased phosphorylated PI-3K, but this was delayed 6-12 h in TNFR1-/- mice.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of PI-3K associated with paracetamol
4) Confidence 0.13 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.54 Pain Relevance 0.85
Akt1 is a component of the phosphoinositide 3'-OH kinase (PI3K) pathway and is phosphorylated in response to Igf1 stimulation of bovine granulosa cells [38].
Positive_regulation (response) of Phosphorylation (phosphorylated) of PI3K in granulosa cells
5) Confidence 0.12 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0

General Comments

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