INT109304

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2011
Negated 5
Speculated 0
Reported most in Abstract
Documents 113
Total Number 114
Disease Relevance 40.92
Pain Relevance 13.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscles 19
adipose tissue 9
mononuclear cells 8
appendix 8
liver 5
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 428 100.00 Very High Very High Very High
agonist 197 99.98 Very High Very High Very High
Clonidine 113 99.86 Very High Very High Very High
Delta opioid receptors 17 99.78 Very High Very High Very High
Calcium channel 44 99.36 Very High Very High Very High
tolerance 355 99.34 Very High Very High Very High
opioid receptor 260 99.20 Very High Very High Very High
antagonist 55 98.56 Very High Very High Very High
Inflammation 304 98.36 Very High Very High Very High
dexamethasone 16 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 546 99.96 Very High Very High Very High
Shock 1107 99.82 Very High Very High Very High
Cancer 340 99.82 Very High Very High Very High
Diabetes Mellitus 486 99.80 Very High Very High Very High
Hypertrophy 313 99.74 Very High Very High Very High
Apoptosis 178 99.46 Very High Very High Very High
Injury 68 99.36 Very High Very High Very High
Insulin Resistance 893 99.32 Very High Very High Very High
Lung Cancer 14 99.16 Very High Very High Very High
Fibrosis 59 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that simvastatin improves the endothelial dysfunction seen in type 2 diabetic mice via increases in Akt and Akt phosphorylation.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt associated with diabetes mellitus
1) Confidence 0.69 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.79 Pain Relevance 0.30
Dexamethasone treatment prevented the decline of mitochondrial potential caused by bupivacaine and increased the levels of Akt phosphorylation.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt associated with dexamethasone
2) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.75 Pain Relevance 0.58
As shown in Figure 5B, Akt protein phosphorylation was gradually activated during myogenic differentiation.
Positive_regulation (activated) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of AKT in striatum
4) Confidence 0.68 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.31
Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of AKT associated with dopamine, antagonist and opioid receptor
5) Confidence 0.68 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.32
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of PKB in mononuclear cells
6) Confidence 0.67 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
The two agonists stimulated Akt phosphorylation and the effect was also abolished by beta-FNA and by LY294002.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Akt associated with agonist
7) Confidence 0.60 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12646285 Disease Relevance 0.40 Pain Relevance 0.64
are one of target proteins of lithium; lithium increases the phosphorylation levels of Akt and GSK3?
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.03 Pain Relevance 0.07
In addition, benidipine treatment augmented the phosphorylation of Akt, indicating that the PI3K/Akt pathway contributed, at least in part, to the endothelial differentiation induced by benidipine.
Positive_regulation (augmented) of Phosphorylation (phosphorylation) of Akt
9) Confidence 0.59 Published 2006 Journal Hypertens. Res. Section Abstract Doc Link 17378377 Disease Relevance 0.12 Pain Relevance 0.06
consistent with the increase of Akt phosphorylation (Fig. 8E).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.28 Pain Relevance 0
The combination of HS and MES induced a sustained enhancement of Akt phosphorylation from 1 h up to 5 h after treatment in insulin-stimulated, high glucose-exposed HepG2 cells (Fig. 9G).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt associated with shock
11) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.03 Pain Relevance 0
We detected that the enhancement of Akt phosphorylation peaked at 1 h after MES treatment and gradually decreased thereafter (Fig. 8H).
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of Akt
12) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.31 Pain Relevance 0
These results strongly suggest that simvastatin improves the endothelial dysfunction seen in type 2 diabetic mice via increases in Akt and Akt phosphorylation.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt associated with diabetes mellitus
13) Confidence 0.50 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.79 Pain Relevance 0.30
We observed an increase of myogenin expression and Akt phosphorylation in the soleus muscles on day 3 after glycerol injection, but it was suppressed in As2O3-treated mice compared with control mice (Figure 8).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Akt in muscles
14) Confidence 0.50 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.25 Pain Relevance 0.04
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of PKB in mononuclear cells
15) Confidence 0.49 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Akt in mononuclear cells
16) Confidence 0.49 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of Akt in mononuclear cells
17) Confidence 0.49 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
In contrast to Zheng et al who examined Ser473 phosphorylation alone, the increase in PKB/Akt phosphorylation was mainly detected on Thr308 in our experiments, and was supported by increased GSK3?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PKB/Akt
18) Confidence 0.48 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
To confirm PTEN knockout in our mice, a dose response curve for insulin stimulated PKB Thr308 phosphorylation was performed (Figure S2).
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PKB associated with targeted disruption
19) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.22 Pain Relevance 0
PI(3,4,5)P3 anchors Akt/PKB to the plasma membrane and induces a conformational change, which results in the phosphorylation of Akt/PKB.
Positive_regulation (results) of Phosphorylation (phosphorylation) of Akt in plasma
20) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0 Pain Relevance 0

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