INT109312

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.55
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1 95.00 High High
Kinase C 5 19.84 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 100.00 Very High Very High Very High
Toxicity 15 99.60 Very High Very High Very High
Drug Induced Neurotoxicity 4 97.60 Very High Very High Very High
Disease 127 96.72 Very High Very High Very High
Neurodegenerative Disease 36 96.48 Very High Very High Very High
Death 56 94.24 High High
Stress 40 92.56 High High
Amyloid Plaque 5 91.80 High High
Aging 5 89.36 High High
Apoptosis 133 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study not only demonstrates the role of GSTP as a direct inhibitor of JNK in vivo but also its role in regulating the constitutive expression of specific downstream molecular targets of the JNK signaling pathway.
Regulation (regulating) of Gene_expression (expression) of JNK
1) Confidence 0.44 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0.10
As shown in Figure 3C, no change was detected in the myocardial levels of FAK (Focal Adhesion Kinase), JNK (c-Jun N-Terminal Kinase) or Shp2 (Src homology region 2, phosphatase 2) after treatment with siMEF2C.
Regulation (detected) of Gene_expression (levels) of JNK associated with adhesions
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.10 Pain Relevance 0
Besides the involvement of the ceramide/JNK pathway, A?
Regulation (involvement) of Gene_expression (pathway) of JNK
3) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.45 Pain Relevance 0

General Comments

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