INT109315

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 70
Total Number 77
Disease Relevance 45.46
Pain Relevance 11.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
spinal cord 5
hepatocytes 3
spinal 2
cardiomyocyte 1
liver 1
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 313 99.88 Very High Very High Very High
nMDA receptor 4 99.56 Very High Very High Very High
agonist 124 99.36 Very High Very High Very High
Paracetamol 57 99.28 Very High Very High Very High
Pain 216 99.02 Very High Very High Very High
Hippocampus 41 98.88 Very High Very High Very High
Hyperalgesia 9 98.80 Very High Very High Very High
dorsal root ganglion 20 98.44 Very High Very High Very High
addiction 13 98.44 Very High Very High Very High
Inflammation 1140 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 299 100.00 Very High Very High Very High
Wallerian Degeneration 87 100.00 Very High Very High Very High
Adhesions 62 100.00 Very High Very High Very High
Reprotox - General 1 393 99.84 Very High Very High Very High
Congenital Anomalies 14 99.84 Very High Very High Very High
Lung Injury 110 99.76 Very High Very High Very High
Toxicity 49 99.60 Very High Very High Very High
Shock 7 99.60 Very High Very High Very High
Cancer 927 99.36 Very High Very High Very High
Aging 151 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible factor would be the protein's high stability resulting in a low turnover rate, as JNK1 is constitutively expressed in the spinal cord [21].
Gene_expression (expressed) of JNK1 in spinal cord associated with spinal cord
1) Confidence 0.78 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.32 Pain Relevance 0.26
Subsequent experiments confirmed that the three splice variants of JNK (JNK1-3) are highly expressed in spinal cord tissue [10].
Gene_expression (expressed) of JNK in spinal cord associated with spinal cord
2) Confidence 0.78 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.70 Pain Relevance 0.40
Subsequent experiments confirmed that the three splice variants of JNK (JNK1-3) are highly expressed in spinal cord tissue [10].
Gene_expression (expressed) of JNK1 in spinal cord associated with spinal cord
3) Confidence 0.78 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.70 Pain Relevance 0.40
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (expression) of JNK
4) Confidence 0.78 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
However, a recent analysis revealed that the 46- and 54-kDa molecules represent two isoforms of JNK1 and JNK2, whereas the 46-kDa JNK1 and 54-kDa JNK2 are dominantly expressed in most cell and tissue types [42].
Gene_expression (expressed) of JNK1
5) Confidence 0.72 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.66 Pain Relevance 0.06
Transfection with JNK siRNA attenuated APAP toxicity after 24 h, suggesting that higher levels of APAP-induced activation of JNK were related to higher rates of cell death.
Gene_expression (Transfection) of JNK associated with toxicity, paracetamol and death
6) Confidence 0.70 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.36 Pain Relevance 0.86
Additional mRNA and protein analysis of Mapk8 in spinal cord tissue
Gene_expression (analysis) of Mapk8 in spinal cord associated with spinal cord
7) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.67 Pain Relevance 0.18
While our experiments focused on Mapk8, one other gene (Pla2g4e) was statistically even more closely linked to formalin test second phase behaviors.
Gene_expression (focused) of Mapk8
8) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.23 Pain Relevance 0.15
It is notable that our haplotypic analysis was only weakly suggestive of a role for Mapk8 genetics in controlling late phase formalin behavior.
Gene_expression (genetics) of Mapk8
9) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.26 Pain Relevance 0.12
We observed minimum or no PAS staining in the mice in the control group, JNK1 KO group, and JNK inhibitor group.
Gene_expression (group) of JNK1
10) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (antibodies) of JNK
11) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.12 Pain Relevance 0
This elevated expression was abrogated by JNK1 mutation and the JNK inhibitor, indicating the dependence of MUC5AC expression on JNK activity.
Gene_expression (mutation) of JNK1 associated with addiction
12) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.53 Pain Relevance 0.05
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Gene_expression (use) of JNK
13) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
Smoke-induced mucus production in the airway of mice through JNK activation
Gene_expression (activation) of JNK
14) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.16 Pain Relevance 0
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Gene_expression (use) of JNK
15) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
This study not only demonstrates the role of GSTP as a direct inhibitor of JNK in vivo but also its role in regulating the constitutive expression of specific downstream molecular targets of the JNK signaling pathway.
Gene_expression (expression) of JNK
16) Confidence 0.66 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0.09
Pharmacologic inhibition of JNK with SP600125 or by expression of dominant negative JNK (JNKDN) decreased the phosphorylation of ?
Neg (negative) Gene_expression (negative) of JNK
17) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.53 Pain Relevance 0
Pharmacologic inhibition of JNK with SP600125 or by expression of dominant negative JNK (JNKDN) decreased the phosphorylation of ?
Gene_expression (expression) of JNK
18) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.53 Pain Relevance 0
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
Gene_expression (Role) of JNK in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
19) Confidence 0.64 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.39 Pain Relevance 0.83
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
Gene_expression (Role) of c-Jun N-terminal kinase in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
20) Confidence 0.64 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.39 Pain Relevance 0.83

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