INT109316

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 72
Total Number 85
Disease Relevance 50.59
Pain Relevance 17.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
hepatocyte 4
liver 4
fat 3
poly 2
lung 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 748 99.92 Very High Very High Very High
Inflammation 1014 99.84 Very High Very High Very High
Buprenorphine 2 99.66 Very High Very High Very High
intrathecal 24 99.42 Very High Very High Very High
addiction 18 99.32 Very High Very High Very High
Morphine 8 99.24 Very High Very High Very High
cINOD 49 99.12 Very High Very High Very High
Opioid 17 98.82 Very High Very High Very High
diclofenac 12 98.80 Very High Very High Very High
Spinal cord 281 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 234 100.00 Very High Very High Very High
Death 240 99.92 Very High Very High Very High
INFLAMMATION 1054 99.84 Very High Very High Very High
Sprains And Strains 477 99.74 Very High Very High Very High
Nociception 52 99.64 Very High Very High Very High
Insulin Resistance 292 99.50 Very High Very High Very High
Hepatocellular Cancer 348 99.44 Very High Very High Very High
Diabetes Mellitus 77 99.36 Very High Very High Very High
Smoke Inhalation Injury 210 99.28 Very High Very High Very High
Enteropathy 5 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally a selective JNK inhibitor blocked late phase formalin behaviors strongly, with no effect whatsoever on early phase behaviors.
Negative_regulation (inhibitor) of JNK
1) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.67 Pain Relevance 0.33
In addition, blockade of JNK using a selective agent reduced late phase formalin licking behavior.
Negative_regulation (blockade) of JNK
2) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.39 Pain Relevance 0.42
Pharmacological inhibition of JNK1 selectively reduces late phase formalin behavior
Negative_regulation (inhibition) of JNK1
3) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.75 Pain Relevance 0.15
This elevated expression was abrogated by JNK1 mutation and the JNK inhibitor, indicating the dependence of MUC5AC expression on JNK activity.
Negative_regulation (inhibitor) of JNK associated with addiction
4) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.53 Pain Relevance 0.05
This study not only demonstrates the role of GSTP as a direct inhibitor of JNK in vivo but also its role in regulating the constitutive expression of specific downstream molecular targets of the JNK signaling pathway.
Negative_regulation (inhibitor) of JNK
5) Confidence 0.57 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0.10
Inhibition of JNK using chemical inhibitors or knocking down JNK can prevent hepatocyte death even in the presence of extensive glutathione (GSH) depletion, covalent binding, and oxidative stress.
Negative_regulation (Inhibition) of JNK in hepatocyte associated with stress and death
6) Confidence 0.53 Published 2010 Journal Handb Exp Pharmacol Section Abstract Doc Link 20020266 Disease Relevance 1.44 Pain Relevance 0.19
Other experiments showed that selective JNK inhibition reduced nociceptive sensitization in a model of diabetic neuropathy [22] and after bee venom or capsaicin injection [23,24].
Negative_regulation (inhibition) of JNK associated with nociception, qutenza and diabetic neuropathy
7) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.85 Pain Relevance 0.49
Finally, intrathecal injections of the selective JNK inhibitor, SP600125, selectively reduced late phase licking behavior.


Negative_regulation (inhibitor) of JNK associated with intrathecal
8) Confidence 0.43 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2831877 Disease Relevance 0.57 Pain Relevance 0.49
The selective JNK inhibitor, SP600125, was used to test the functional link between Mapk8 and late phase formalin behavior.
Negative_regulation (inhibitor) of JNK
9) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.77 Pain Relevance 0.20
The non peptide JNK inhibitor, SP600125 (anthra [1,9-cd]pyrazol-6(2H)-one), was purchased from Sigma (St.
Negative_regulation (inhibitor) of JNK
10) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0 Pain Relevance 0.13
Using spinal nerve ligation to create a model of neuropathic pain, Zhuang et al. demonstrated that the up-regulation of JNK1 occurred primarily in spinal astrocytes, and that the spinal administration of a selective JNK1 inhibitor blocked the resulting hypersensitivity [21].
Negative_regulation (inhibitor) of JNK1 in spinal associated with eae, hypersensitivity and neuropathic pain
11) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.84 Pain Relevance 0.48
In addition, the mice subjected to 15 min of smoke inhalation followed by a 4-h recovery period were divided into 3 groups: wild-type, WS4; JNK1-/-, JKOC4; and wild type administered the JNK inhibitor, JIS4.
Negative_regulation (inhibitor) of JNK
12) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.08 Pain Relevance 0
The control group mice were further divided into 3 groups: wild-type, WC; JNK1-/-, JKOC; and wild-type administered the JNK inhibitor, JIC.
Negative_regulation (inhibitor) of JNK
13) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.09 Pain Relevance 0
Wild-type JNK1 -/- mice and the wild-type mice injected with the JNK inhibitor were assigned to one of 3 groups: one was the control group; mice in the second group were subjected to cotton smoke inhalation for 15 min followed by a 4-h recovery period; and mice in the third group were subjected to cotton smoke inhalation for 15 min followed by a 24-h recovery period.
Negative_regulation (inhibitor) of JNK
14) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0.12
Three groups of mice were subjected to the smoke inhalation injury: (1) wild-type (WT) mice, (2) mice lacking JNK1 (JNK1-/- mice), and (3) WT mice administered a JNK inhibitor.
Negative_regulation (inhibitor) of JNK associated with smoke inhalation injury
15) Confidence 0.43 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.64 Pain Relevance 0
The control group mice were further divided into 3 groups: wild-type, WC; JNK1-/-, JKOC; and wild-type administered the JNK inhibitor, JIC.
Negative_regulation (inhibitor) of JNK1
16) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.09 Pain Relevance 0.03
Although three was a trend to less obstruction in JNK -/- mice than JNK inhibitor, the results did not reach to statistical significant (Table 1).


Negative_regulation (inhibitor) of JNK
17) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
A JNK inhibitor dose of 30 mg/kg was selected on the basis of previous in vivo studies that showed that this dose inhibits JNK activity [8,15,16].
Negative_regulation (inhibits) of JNK
18) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.09 Pain Relevance 0.09
The dose was chosen on the basis of previous in vivo studies that showed 30 mg/kg inhibited JNK activity [12,13].
Negative_regulation (inhibited) of JNK
19) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.40 Pain Relevance 0
Three groups of mice were subjected to the smoke inhalation injury: (1) wild-type (WT) mice, (2) mice lacking JNK1 (JNK1-/- mice), and (3) WT mice administered a JNK inhibitor.
Negative_regulation (lacking) of JNK1 associated with smoke inhalation injury
20) Confidence 0.43 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.59 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox