INT109328

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.78
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FLT3)
Anatomy Link Frequency
stem 2
bone marrow 1
blood cells 1
FLT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 95.76 Very High Very High Very High
Pain 18 95.36 Very High Very High Very High
nud 5 73.52 Quite High
antagonist 3 50.68 Quite High
cytokine 12 16.00 Low Low
imagery 11 8.28 Low Low
cva 14 5.00 Very Low Very Low Very Low
dexamethasone 11 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 32 99.76 Very High Very High Very High
Ovarian Cancer 100 96.96 Very High Very High Very High
Vomiting 18 96.72 Very High Very High Very High
Sleep Disorders 1 96.16 Very High Very High Very High
Headache 3 95.76 Very High Very High Very High
Pain 16 95.36 Very High Very High Very High
Myelodysplastic Syndromes 18 93.00 High High
Leukemia 25 91.60 High High
Disease 23 78.64 Quite High
Fatigue 34 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As biomarkers, VEGF RNA expression by leukemic blasts, bone marrow MVD, and the expression of the target receptors c-kit, Flt3, VEGFR-1, and VEGFR-2 prior to therapy was determined.
Gene_expression (expression) of Flt3 in bone marrow
1) Confidence 0.61 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.97 Pain Relevance 0.22
One multitarget agent in this emerging antineoplastic category includes sunitinib, which acts as an intracellular tyrosine kinase inhibitor (TKI) of multiple factors, including the intracellular domain of VEGF receptor (VEGFR-1, VEGFR-2), PDGF receptor (PDGFR-alpha and PDGF-beta), fetal liver tyrosine kinase receptor 3 (FLT3), and KIT (stem-cell factor receptor).9,10
Gene_expression (receptor) of FLT3 in stem
2) Confidence 0.19 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886329 Disease Relevance 0.57 Pain Relevance 0
One multitarget agent in this emerging antineoplastic category includes sunitinib, which acts as an intracellular tyrosine kinase inhibitor (TKI) of multiple factors, including the intracellular domain of VEGF receptor (VEGFR-1, VEGFR-2), PDGF receptor (PDGFR-alpha and PDGF-beta), fetal liver tyrosine kinase receptor 3 (FLT3), and KIT (stem-cell factor receptor).9,10
Gene_expression (receptor) of tyrosine kinase receptor 3 in stem
3) Confidence 0.19 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886329 Disease Relevance 0.57 Pain Relevance 0
AML blasts may express VEGFR-2, c-kit, and FLT3.
Gene_expression (express) of FLT3 associated with myeloid leukemia
4) Confidence 0.17 Published 2003 Journal Blood Section Abstract Doc Link 12649163 Disease Relevance 1.09 Pain Relevance 0.12
Sunitinib (SUN) is an orally bioavailable small molecule that inhibits multiple tyrosine kinases including all the PDGF receptors and VEGF receptors, as well as c-kit, RET, CSF-1R, and flt-3.
Gene_expression (receptors) of flt-3
5) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.37 Pain Relevance 0.04
In other studies, McGuckin et al demonstrated that culture of cord blood cells that have been depleted of lineage committed cells in a TPO, c-kit, and flt-3 ligand culture express markers of embryonic stem cells including TRA-1–60, TRA-1–81, SSEA-4, SSEA-3 and Oct-4.
Gene_expression (express) of flt-3 in blood cells
6) Confidence 0.06 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796850 Disease Relevance 0.21 Pain Relevance 0

General Comments

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