INT10933

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Context Info
Confidence 0.18
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.30
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnnm2)
Anatomy Link Frequency
spinal cord 3
neuronal 1
pore 1
striatum 1
internal 1
Cnnm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 15 98.16 Very High Very High Very High
Kinase C 2 85.04 High High
substance P 8 80.80 Quite High
Somatostatin 6 68.40 Quite High
bradykinin 2 68.32 Quite High
Neuropeptide 4 65.84 Quite High
antagonist 16 57.52 Quite High
Enkephalin 11 57.16 Quite High
calcitonin gene related peptide 3 56.48 Quite High
Neurotransmitter 21 50.56 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4 79.68 Quite High
Vomiting 17 20.00 Low Low
Syndrome 8 18.32 Low Low
Vertigo 23 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Nystagmus 11 5.00 Very Low Very Low Very Low
Dizziness 6 5.00 Very Low Very Low Very Low
Headache 5 5.00 Very Low Very Low Very Low
Vestibular Diseases 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Gene_expression (levels) of m2 in spinal cord
1) Confidence 0.18 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Gene_expression (levels) of m2 in spinal cord
2) Confidence 0.18 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Gene_expression (levels) of m2 in spinal cord
3) Confidence 0.16 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
METHODS: The mRNA expression level of m1, m2, m3, m4 and m5 were determined by RT-PCR, the beta-actin mRNA expression was used as internal control.
Gene_expression (expression) of m2 in internal
4) Confidence 0.08 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
Our observations demonstrate that m1, m2, and m4 receptor genes are expressed in one or several phenotypically distinct neuronal populations.
Gene_expression (expressed) of m2 in neuronal
5) Confidence 0.06 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527598 Disease Relevance 0 Pain Relevance 0.07
Neurons expressing the m1, m2, and m4 muscarinic receptor genes in the adult rat striatum were identified and characterized by using several in situ hybridization and immunohistochemical procedures.
Gene_expression (expressing) of m2 in striatum
6) Confidence 0.05 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527598 Disease Relevance 0 Pain Relevance 0
Monomeric peptides and four-helix bundle proteins with amino acid sequences of the predicted transmembrane segment M2 of nicotinic acetylcholine receptors (AChR) were designed, synthesized, and used as probes to elucidate the pore-forming structure of the authentic AChR channel.
Gene_expression (synthesized) of M2 in pore
7) Confidence 0.03 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 7686900 Disease Relevance 0 Pain Relevance 0
In addition to nicotinic receptors, muscarinic receptors (m1, m2 and m5) were expressed in human vestibular afferent neurons, whereas in the rat, five subtypes of muscarinic receptors (m1 - m5) are found [160].
Gene_expression (expressed) of m2 in afferent neurons
8) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0 Pain Relevance 0.14
In order to investigate whether cell-surface receptor activity can regulate APP processing, HEK 293 cell lines stably expressing human muscarinic acetylcholine receptors (mAChR; subtypes m1, m2, m3, m4) were stimulated with the muscarinic agonist carbachol, and the release of APP derivatives was measured.
Gene_expression (expressing) of m2 associated with agonist
9) Confidence 0.01 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.15 Pain Relevance 0.08
Carbachol increased the release of large amino-terminal APP-fragments 4- to 6-fold in cell lines expressing the m1 or m3 receptors but not in those expressing m2 or m4 subtypes.
Gene_expression (expressing) of m2
10) Confidence 0.01 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.14 Pain Relevance 0.16

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