INT109334

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 7.48
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
joint 3
MIA PaCa-2 2
SH-SY5Y 1
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 400 100.00 Very High Very High Very High
Antinociceptive 2 92.80 High High
alcohol 36 89.12 High High
Osteoarthritis 54 80.84 Quite High
cINOD 188 79.04 Quite High
Codeine 8 75.00 Quite High
Opioid 2 67.80 Quite High
Inflammation 21 46.40 Quite Low
cytokine 20 43.20 Quite Low
Chronic pancreatitis 2 36.96 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 56 99.44 Very High Very High Very High
Breast Cancer 187 99.16 Very High Very High Very High
Apoptosis 254 97.64 Very High Very High Very High
Cancer 101 97.60 Very High Very High Very High
Injury 20 94.00 High High
Prostate Cancer 13 85.64 High High
Endometriosis (extended) 12 85.64 High High
Disease 17 81.16 Quite High
Osteoarthritis 54 80.84 Quite High
Pancreatic Cancer 12 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations confirm the regulation of SOD2 functions following a drug treatment; however, the differences observed among the various experimental systems indicate that the SOD2 response is a multifactorial process only poorly clarified.
Regulation (regulation) of SOD2
1) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.20 Pain Relevance 0.16
Therefore, a transcriptional regulation of the SOD2 gene by diclofenac could be excluded; probably, an increased degradation of the protein levels could explain the reduced activity of the enzyme.
Regulation (regulation) of SOD2 gene associated with diclofenac
2) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.38 Pain Relevance 0.24
Codeinone did not significantly change the manganese superoxide dismutase (MnSOD) activity nor its mRNA expression.
Neg (nor) Regulation (change) of MnSOD
3) Confidence 0.58 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 0.97 Pain Relevance 0.25
Verification of the modulation of GRP78 and SOD2
Regulation (modulation) of SOD2
4) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.14 Pain Relevance 0.07
The latter two studies thus had insufficient power to fully investigate the joint effects of the MnSOD genotype and intake of dietary antioxidants.
Spec (investigate) Regulation (effects) of MnSOD in joint
5) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.45 Pain Relevance 0.03
Modest joint effects for the MnSOD genotype and smoking were observed in our study.
Regulation (effects) of MnSOD in joint associated with nicotine addiction
6) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.48 Pain Relevance 0.03
The ORs estimating the joint effects of the MnSOD genotype and several environmental exposures are presented in Table 3.
Regulation (effects) of MnSOD in joint
7) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.57 Pain Relevance 0.04
The effects of the MnSOD genotype also appear to depend upon environmental exposures that increase or decrease the levels of ROS, and such exposures may differ across populations.
Regulation (effects) of MnSOD
8) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.31 Pain Relevance 0.05
Codeinone did not significantly change the manganese superoxide dismutase (MnSOD) activity nor its mRNA expression.
Neg (nor) Regulation (change) of manganese superoxide dismutase
9) Confidence 0.37 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 0.97 Pain Relevance 0.25
Effect of Diclofenac on SOD2 Levels
Regulation (Effect) of SOD2 associated with diclofenac
10) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.23 Pain Relevance 0.42
For instance, stautosporine, a protein kinase inhibitor, did not affect the mRNA levels of SOD1 and SOD2, but decreased protein and activity levels of both enzymes [48].
Neg (not) Regulation (affect) of SOD2
11) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.30 Pain Relevance 0.17
To this aim, the dose- and time-dependent effects of this drug on SOD2 protein levels of SH-SY5Y cells were analysed in the experiments reported in Figure 3.
Spec (analysed) Regulation (effects) of SOD2 protein in SH-SY5Y
12) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.21 Pain Relevance 0.38
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Regulation (immunoreactivity) of MnSOD in MIA PaCa-2
13) Confidence 0.26 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.48 Pain Relevance 0
We also carried out Western blot analyses to examine SOD2 modulation at the protein level.
Spec (examine) Regulation (modulation) of SOD2
14) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.16 Pain Relevance 0.04
Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.
Regulation (immunoreactivity) of MnSOD in MIA PaCa-2
15) Confidence 0.23 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.48 Pain Relevance 0
Calcitriol treatment results in reduced mRNA and protein levels of RelB and its target genes survivin, Bcl-2 and MnSOD, and sensitizes the breast cancer cells Hs578T and NF639 to gamma-irradiation.
Regulation (target) of MnSOD associated with breast cancer
16) Confidence 0.10 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.14 Pain Relevance 0

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