INT109374

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ppp1cc, Ppp2r1a) chromosome (Ppp1cc, Ppp2r1a) mitochondrion (Ppp1cc)
chromosome segregation (Ppp2r1a) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
Ppp1cc (Mus musculus)
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 99.16 Very High Very High Very High
antinociception 4 98.48 Very High Very High Very High
Antinociceptive 2 94.08 High High
opioid receptor 1 78.04 Quite High
tail-flick 2 75.00 Quite High
narcan 4 74.12 Quite High
Pain 1 25.00 Low Low
nociceptor 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, high doses of okadaic acid (10 ng/mouse, i.c.v.) and cantharidin (1 microg/mouse, i.c.v.), which also block PP1, and calyculin-A (0.1 fg/mouse-1 ng/mouse, i.c.v.), which inhibits equally both PP1 and PP2A, did not modify the morphine-induced antinociception.
PP1 Negative_regulation (inhibits) of PP2A associated with antinociception and morphine
1) Confidence 0.24 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12650833 Disease Relevance 0 Pain Relevance 1.11

General Comments

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