INT109379

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 4
Speculated 7
Reported most in Abstract
Documents 22
Total Number 30
Disease Relevance 12.58
Pain Relevance 18.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 9
spinal 8
dorsal horn 4
colon 3
sensory neurons 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 139 100.00 Very High Very High Very High
c fibre 18 100.00 Very High Very High Very High
noradrenaline 11 100.00 Very High Very High Very High
Cannabinoid 8 99.90 Very High Very High Very High
nMDA receptor 64 99.84 Very High Very High Very High
Dorsal horn neuron 15 99.80 Very High Very High Very High
Opioid 55 99.56 Very High Very High Very High
opioid receptor 77 99.54 Very High Very High Very High
Dorsal horn 30 99.44 Very High Very High Very High
Inflammation 180 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 39 99.40 Very High Very High Very High
INFLAMMATION 159 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.30 Very High Very High Very High
Arthralgia 11 99.20 Very High Very High Very High
Diabetes Mellitus 132 98.56 Very High Very High Very High
Pain 177 98.52 Very High Very High Very High
Stress 86 98.42 Very High Very High Very High
Cv Unclassified Under Development 2 97.52 Very High Very High Very High
Ganglion Cysts 90 97.48 Very High Very High Very High
Neuritis 4 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that intermittent claudication triggered by forced walking might affect the phosphorylation of ERK in the superficial laminae, possibly via transient (partial) ischemia of the spinal cord.
Spec (might) Regulation (affect) of Phosphorylation (phosphorylation) of ERK in spinal cord associated with ischemia, restless leg syndrome and spinal cord
1) Confidence 0.59 Published 2004 Journal Pain Section Abstract Doc Link 15082127 Disease Relevance 0.92 Pain Relevance 0.80
In vivo regulation of extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphine.
Regulation (regulation) of Phosphorylation (phosphorylation) of ERK associated with morphine
2) Confidence 0.58 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.72
This experiment was critical, because it allowed us to test whether the influence of the vlPAG on the amygdala and mPFC is evident only when an extinction memory is formed, or if opioid receptor blockade in the vlPAG affects ERK phosphorylation related to retrieval and/or reconsolidation of memory.
Spec (whether) Regulation (affects) of Phosphorylation (phosphorylation) of ERK in amygdala associated with opioid receptor and amygdala
3) Confidence 0.54 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.08 Pain Relevance 0.30
In this study, we examined whether opioids and cannabinoids can affect C-fiber-induced ERK phosphorylation (pERK) in dorsal horn neurons in spinal cord slices from normal and spinal nerve-ligated rats.
Regulation (affect) of Phosphorylation (phosphorylation) of pERK in neurons associated with c fibre, cannabinoid, dorsal horn neuron, opioid and spinal cord
4) Confidence 0.52 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.48 Pain Relevance 2.03
The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses.
Regulation (regulated) of Phosphorylation (phosphorylation) of ERK
5) Confidence 0.45 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.45 Pain Relevance 0.32
In the peripheral nervous system, the ATP receptor, P2X3, seems to play an important role in regulating ERK phosphorylation in DRG neurons, especially in models of inflammatory joint pain [6, 83].
Regulation (regulating) of Phosphorylation (phosphorylation) of ERK in neurons associated with pain, arthralgia, inflammation and peripheral nervous system
6) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.48 Pain Relevance 0.64
Traditionally, spinal ERK phosphorylation has been assumed to depend exclusively on sensory afferent input.
Regulation (depend) of Phosphorylation (phosphorylation) of ERK in spinal
7) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.13 Pain Relevance 0.53
In this study, we examined whether opioids and cannabinoids can affect C-fiber-induced ERK phosphorylation (pERK) in dorsal horn neurons in spinal cord slices from normal and spinal nerve-ligated rats.
Regulation (affect) of Phosphorylation (phosphorylation) of ERK in neurons associated with c fibre, cannabinoid, dorsal horn neuron, opioid and spinal cord
8) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.48 Pain Relevance 2.02
Despite the fact that CPP disrupted extinction both within and between sessions, it did not affect ERK phosphorylation in the mPFC.
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of ERK
9) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.19 Pain Relevance 0.52
We examined the roles of phosphorylation of extracellular signal-regulated protein kinases (pERK) in regulating the excitability of neurons in the dorsal root ganglion (DRG) after chronic compression.
Spec (examined) Regulation (roles) of in neurons Phosphorylation (phosphorylation) of pERK in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
10) Confidence 0.38 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17490811 Disease Relevance 0.42 Pain Relevance 0.25
In what concerns spinal ERK phosphorylation after visceral inflammation, the scarce studies available show that noxious stimulation of the chronic inflamed colon and bladder induces prolonged and intense ERK activation in the lumbosacral spinal cord [24, 36] where most of the primary afferents innervating these organs terminate.
Regulation (concerns) of Phosphorylation (phosphorylation) of ERK in colon associated with inflammation and spinal cord
11) Confidence 0.38 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.65 Pain Relevance 0.55
Effect of peripheral capsaicin receptor blockage on ERK phosphorylation in Vc and C1-C2 neurons
Regulation (Effect) of Phosphorylation (phosphorylation) of ERK in neurons associated with qutenza
12) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2661045 Disease Relevance 0.48 Pain Relevance 0.74
Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root.
Regulation (Changes) of Phosphorylation (phosphorylation) of ERK in dorsal horn associated with neuritis and dorsal horn neuron
13) Confidence 0.36 Published 2003 Journal Brain Res. Section Title Doc Link 12650969 Disease Relevance 0.33 Pain Relevance 0.49
Because delta opioid receptors can activate the p42/44 MAPKs, extracellular signal regulated kinases (ERK), we determined the effects of DPDPE on ERK phosphorylation.
Spec (determined) Regulation (effects) of Phosphorylation (phosphorylation) of ERK associated with delta opioid receptors
14) Confidence 0.31 Published 2006 Journal Horm Behav Section Abstract Doc Link 16289112 Disease Relevance 0.08 Pain Relevance 0.33
To investigate whether the phosphorylation of extracellular signal-regulated kinase (ERK) is involved in autoimmune injury of the peripheral nervous system (PNS), the expression of phosphorylated ERK (p-ERK) was analyzed in experimental autoimmune neuritis (EAN) in rats.
Spec (whether) Regulation (involved) of Spec (whether) Phosphorylation (phosphorylation) of ERK in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, injury and neuritis
15) Confidence 0.27 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 0.56 Pain Relevance 0.50
This serves as evidence of the importance of ERK phosphorylation in the peripheral processes of sensory neurons.
Regulation (importance) of Phosphorylation (phosphorylation) of ERK in sensory neurons
16) Confidence 0.26 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 1.49 Pain Relevance 0.97
The present findings suggest that tooth-pulp-driven neurons in the spinal trigeminal nucleus are involved in tooth pulp pain through activation of the intracellular signal transduction pathway that involves earlier ERK phosphorylation and subsequent Fos expression.
Regulation (involves) of Phosphorylation (phosphorylation) of ERK in tooth pulp associated with pain
17) Confidence 0.25 Published 2006 Journal Brain Res. Section Abstract Doc Link 16442086 Disease Relevance 0.15 Pain Relevance 0.40
Although CPP delivered to the BLA disrupted extinction learning both within (Figures 2 and 6) and across session (Figure 2), blocking NMDA receptors had no affect on ERK phosphorylation in the mPFC.


Neg (no) Regulation (affect) of Phosphorylation (phosphorylation) of ERK associated with nmda receptor
18) Confidence 0.24 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.27 Pain Relevance 0.26
However, neither the phosphorylated extracellular signal-regulated kinase (p-ERK) nor phosphorylated c-Jun NH2-terminal kinase (p-JNK) was affected.
Neg (neither) Regulation (affected) of Phosphorylation (phosphorylated) of ERK
19) Confidence 0.23 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.45 Pain Relevance 0.71
However, neither the phosphorylated extracellular signal-regulated kinase (p-ERK) nor phosphorylated c-Jun NH2-terminal kinase (p-JNK) was affected.
Neg (neither) Regulation (affected) of Phosphorylation (phosphorylated) of ERK
20) Confidence 0.23 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.45 Pain Relevance 0.69

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