INT109403

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 6
Speculated 7
Reported most in Body
Documents 31
Total Number 38
Disease Relevance 31.22
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
colon 4
endothelial cells 2
hepatocytes 2
HeLa 2
bone marrow 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.64 Very High Very High Very High
Potency 4 99.56 Very High Very High Very High
qutenza 12 97.38 Very High Very High Very High
ischemia 23 97.04 Very High Very High Very High
cytokine 68 92.80 High High
dexamethasone 127 92.00 High High
antagonist 5 91.24 High High
cINOD 18 89.28 High High
Pain 30 88.16 High High
Kinase C 14 84.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1117 100.00 Very High Very High Very High
Metastasis 124 100.00 Very High Very High Very High
Skin Cancer 70 100.00 Very High Very High Very High
Death 232 99.92 Very High Very High Very High
Chronic Lymphoid Leukemia 22 99.84 Very High Very High Very High
Cancer 744 99.82 Very High Very High Very High
Congenital Anomalies 10 99.76 Very High Very High Very High
Adhesions 137 99.48 Very High Very High Very High
Melanoma 6 99.42 Very High Very High Very High
Malignant Neoplastic Disease 31 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologic scavenging study of reactive oxygen species (ROS) revealed that synergistic augmentation of cytotoxicity was achieved by generation of ROS, which might modulate the expression of Bcl-2 family proteins, the activity of caspase-3, and mitochondrial membrane potential transition.
Spec (might) Regulation (modulate) of Gene_expression (expression) of Bcl-2
1) Confidence 0.60 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685442 Disease Relevance 0.52 Pain Relevance 0.13
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.
Regulation (regulation) of Gene_expression (expressions) of Bcl-2 associated with prostate cancer and apoptosis
2) Confidence 0.46 Published 2006 Journal Biol. Pharm. Bull. Section Title Doc Link 16880611 Disease Relevance 1.53 Pain Relevance 0.09
In addition, the expression of bcl-2 in CM metastases was evaluated without comparison to bcl-2 expression in normal melanocytes.
Regulation (evaluated) of Gene_expression (expression) of bcl-2 in melanocytes associated with skin cancer and metastasis
3) Confidence 0.44 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.11 Pain Relevance 0
This data suggests that alterations in expression and phosphorylation of Bcl-2 family proteins may underlie the increase in NPC viability induced by PACAP.
Regulation (alterations) of Gene_expression (expression) of Bcl-2
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.10 Pain Relevance 0.10
A mitochondrial permeability transition pore activator significantly abolished the anti-apoptotic effect of nicorandil in endothelial cells, indicating that the mechanism of protective effect of nicorandil is involved in the mitochondrial apoptotic pathway although it affects neither Bcl-2 nor Bax protein expression levels.
Neg (neither) Regulation (affects) of Neg (neither) Gene_expression (expression) of Bcl-2 in endothelial cells associated with apoptosis
5) Confidence 0.43 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16306793 Disease Relevance 0.94 Pain Relevance 0.05
Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.
Regulation (Modulation) of Gene_expression (expression) of Bcl-2 in hepatocytes associated with apoptosis
6) Confidence 0.41 Published 2003 Journal Int J Artif Organs Section Title Doc Link 12653348 Disease Relevance 0.37 Pain Relevance 0
Deregulated expression of the Bcl-2 protein represents the best-known example of a potent blocker of apoptosis.
Regulation (Deregulated) of Gene_expression (expression) of Bcl-2 associated with apoptosis
7) Confidence 0.40 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.48 Pain Relevance 0.04
Bcl-2 production is controlled by a gene located on chromosome 18 [14].
Regulation (controlled) of Gene_expression (production) of Bcl-2
8) Confidence 0.38 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.73 Pain Relevance 0
We determined the effect of ectopic Bcl-2 expression upon sulindac-induced apoptotic signaling in SW480 human colon cancer cells.
Spec (determined) Regulation (effect) of Gene_expression (expression) of Bcl-2 in colon associated with colon cancer and apoptosis
9) Confidence 0.36 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.00 Pain Relevance 0.17
The expression of caspase-3, Bcl-2, and p53 was evaluated by immunohistochemistry

Results

Regulation (evaluated) of Gene_expression (expression) of Bcl-2
10) Confidence 0.31 Published 2006 Journal Head Face Med Section Abstract Doc Link PMC1524725 Disease Relevance 1.38 Pain Relevance 0.11
Despite the different patterns of Bcl-2 expression in the first part of the menstrual cycle, the results from those two studies suggest that the regulation of Bcl-2 expression in breast tissue is hormone-dependent.
Regulation (regulation) of Gene_expression (expression) of Bcl-2
11) Confidence 0.30 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1143573 Disease Relevance 0.56 Pain Relevance 0
We determined the effects of exercise on bcl-2 family upstream of caspase-3, including caspase-9 and bax: bcl-2 ratio.
Spec (determined) Regulation (effects) of Gene_expression (ratio) of bcl-2
12) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.18 Pain Relevance 0
We determined the effects of exercise on bcl-2 family upstream of caspase-3, including caspase-9 and bax: bcl-2 ratio.
Spec (determined) Regulation (effects) of Gene_expression (ratio) of bcl-2
13) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.18 Pain Relevance 0
Compared to CTL cells, a rise in Bax:Bcl-2 ratio (panel D, Fig. 4) in cells exposed to TMZ was influenced more by a change in Bax expression (panel A, Fig. 4) than a change in Bcl-2 expression (panel B, Fig. 4).
Regulation (change) of Gene_expression (expression) of Bcl-2
14) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.32 Pain Relevance 0.20
We also examined the level of Bcl-2 expression in all treatment groups (panel B, Fig. 4).
Spec (examined) Regulation (level) of Gene_expression (expression) of Bcl-2
15) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.40 Pain Relevance 0.17
It has been shown that the treatment of melanoma cells with oligonucleotides targeting the reduction of bcl-2 expression rendered those cells more sensitive to chemotherapy [5,36-41].
Regulation (targeting) of Gene_expression (expression) of bcl-2 associated with melanoma
16) Confidence 0.27 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.63 Pain Relevance 0
In addition, mesalazine induced apoptosis in colon cancer cells possibly through activation of caspase-3 whereas the levels of bcl-2 family proteins were not altered.
Neg (not) Regulation (altered) of Gene_expression (levels) of bcl-2 in colon associated with colon cancer and apoptosis
17) Confidence 0.26 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663503 Disease Relevance 0.80 Pain Relevance 0.24
Moreover, the reduced DCs yielded in db/db bone marrow culture was attributed to significantly increased apoptosis, which was associated with dysregulated expression of Bcl-2 family genes [39].
Regulation (dysregulated) of Gene_expression (expression) of Bcl-2 in bone marrow associated with apoptosis
18) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.15 Pain Relevance 0.04
Treatment of breast cancer using these endocrine strategies may induce cell death by altered expression of Bcl-2 family proteins, altered expression of cell cycle associated proteins [13,27,28] or by other mechanisms.
Regulation (altered) of Gene_expression (expression) of Bcl-2 associated with breast cancer and death
19) Confidence 0.26 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0.91 Pain Relevance 0.10
In addition to the rarity of the tumor, the present case suggests the malignant potency of the tumor despite lack of bcl-2 and p53 expression, which has been known as a marker for malignancy of neuroendocrine tumors [2-5].


Regulation (lack) of Gene_expression (expression) of bcl-2 associated with malignant neoplastic disease, neuroendocrine cancer, cancer and potency
20) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.30 Pain Relevance 0.05

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