INT109404

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.49
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
nucleus 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 95.44 Very High Very High Very High
Central nervous system 10 90.36 High High
agonist 5 87.84 High High
Kinase C 53 87.16 High High
lidocaine 1 85.80 High High
Inflammation 29 45.60 Quite Low
cINOD 3 44.08 Quite Low
cytokine 22 5.00 Very Low Very Low Very Low
ischemia 14 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 175 100.00 Very High Very High Very High
Ataxia 1 98.96 Very High Very High Very High
Breast Cancer 11 98.76 Very High Very High Very High
Cancer 64 97.08 Very High Very High Very High
Stroke 37 94.92 High High
Prostate Cancer 13 86.56 High High
Death 64 83.92 Quite High
Drug Induced Neurotoxicity 4 82.16 Quite High
Immunotherapy Of Cancer 2 79.72 Quite High
Skin Cancer 21 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They claim that, in the estradiol-treated group, STAT-3 is phosphorylated and translocates into the nucleus to promote transcription of the Bcl-2 family of proteins.
Transcription (transcription) of Bcl-2 in nucleus
1) Confidence 0.69 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.30 Pain Relevance 0
Total RNA was extracted by northern blotting analysis and for Bcl-2, Bax and beta-actin RNA messenger detection, RT-PCR amplification was used.
Transcription (detection) of Bcl-2 associated with apoptosis
2) Confidence 0.63 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12653348 Disease Relevance 0.64 Pain Relevance 0.09
These events were associated with rapid co-ordinated transcription of pro-apoptotic genes including Fas/CD95, Bcl-2 and caspase families and ataxia telangiectasia mutated (ATM)/CHK2/p53 DNA damage response pathway.
Transcription (transcription) of Bcl-2 associated with ataxia and apoptosis
3) Confidence 0.25 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.97 Pain Relevance 0.56
Besides the transcription factors c-myc and Bcl-2, which were obvious candidates for the potential link between Receptor Ck and hTERT expression, we also examined cyclin D and peroxisome proliferator-activated receptor ?
Transcription (transcription) of Bcl-2
4) Confidence 0.21 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.46 Pain Relevance 0.05
Calcitriol treatment results in reduced mRNA and protein levels of RelB and its target genes survivin, Bcl-2 and MnSOD, and sensitizes the breast cancer cells Hs578T and NF639 to gamma-irradiation.
Transcription (levels) of Bcl-2 associated with breast cancer
5) Confidence 0.15 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.20 Pain Relevance 0
Phosphorylation and degradation of IkB, the inhibitory subunit that sequesters the NF-kB complex in the cytoplasm, releases NF-kB which can traslocate to the nucleus and activate the transcription of genes that promote resistance to apoptosis, such as MnSOD, Bcl-2 and members of the Inhibitor of Apoptosis Proteins (IAPs) family.
Transcription (transcription) of Bcl-2 in nucleus associated with apoptosis
6) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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