INT109408

Context Info Confidence 0.06 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.23

cytoplasm (APC, RASGRP1) cytosol (APC, RASGRP1) plasma membrane (APC, RASGRP1) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1)

APC (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 97.04 Inflammation 1 96.56

Disease Link Frequency Relevance Heat Familial Adenomatous Polyposis 3 100.00 Cancer 2 100.00 INFLAMMATION 1 96.56 Intestinal Cancer 2 75.00 Colon Cancer 2 74.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inactivation of the APC tumour-suppressor gene, and the activation of K-ras, have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines.

Negative_regulation (Inactivation) of APC tumour-suppressor gene Negative_regulation (decreased) of Positive_regulation (activation) of ras associated with cancer and familial adenomatous polyposis

1) Confidence 0.06 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.73 Pain Relevance 0.23

General Comments

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