INT109411

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 61
Total Number 73
Disease Relevance 67.99
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAT1) small molecule metabolic process (SAT1) intracellular (SAT1)
transferase activity, transferring acyl groups (SAT1) cellular nitrogen compound metabolic process (SAT1) cytoplasm (SAT1)
Anatomy Link Frequency
plasma 8
adipose tissue 3
lung 2
adipocytes 2
fat 1
SAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 245 100.00 Very High Very High Very High
cytokine 211 97.44 Very High Very High Very High
Inflammation 594 95.32 Very High Very High Very High
cINOD 52 93.04 High High
Inflammatory response 36 89.72 High High
corticosteroid 12 87.20 High High
antagonist 12 82.00 Quite High
Potency 7 81.20 Quite High
Cannabinoid receptor 49 79.08 Quite High
agonist 15 57.76 Quite High
Disease Link Frequency Relevance Heat
Obesity 8058 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1258 100.00 Very High Very High Very High
Prostate Cancer 22 99.90 Very High Very High Very High
Injury 362 99.48 Very High Very High Very High
Lung Injury 216 99.42 Very High Very High Very High
Weight Loss 192 99.28 Very High Very High Very High
Birth Weight 36 98.92 Very High Very High Very High
Colorectal Cancer 437 98.68 Very High Very High Very High
Insulin Resistance 90 98.64 Very High Very High Very High
Reprotox - General 1 1 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and SSAT expression, as well as higher SSAT activity, in mutated K-ras samples.
Gene_expression (expression) of SSAT
1) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.61 Pain Relevance 0
and SSAT expression as well as in SSAT activity.
Gene_expression (expression) of SSAT
2) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.52 Pain Relevance 0
and SSAT expression both in normal and neoplastic human colorectal tissues.
Gene_expression (expression) of SSAT
3) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.57 Pain Relevance 0
On the other hand, in prostatic cancer the SSAT overexpression induces growth inhibition without determining polyamine pool depletion since SSAT activity seems to modulate ODC activity [11,34].
Gene_expression (overexpression) of SSAT associated with prostate cancer
4) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.79 Pain Relevance 0
On the contrary, a Min mouse model in which SSAT expression promotes tumorigenesis has been proposed. [32].
Gene_expression (expression) of SSAT
5) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.57 Pain Relevance 0
could increase SSAT expression in these cells [15].
Gene_expression (expression) of SSAT
6) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.47 Pain Relevance 0
induces SSAT expression and influences polyamine availability, regulating cell proliferation and differentiation.
Gene_expression (expression) of SSAT
7) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.45 Pain Relevance 0
This PPAR, in turn, activates the expression of the spermidine/spermine-N(1)-acetyltransferase (SSAT), the first enzyme in polyamine catabolism.
Gene_expression (expression) of SSAT
8) Confidence 0.74 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.74 Pain Relevance 0.20
and SSAT expression, as well as higher SSAT activity, in mutated K-ras samples.
Gene_expression (expression) of SSAT
9) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.61 Pain Relevance 0
Recently, Babbar et al. [5] demonstrated that in colorectal tumour cells, the promoter of spermidine/spermine N1-acetyltransferase (SSAT) gene contains a functional PPAR responsive element and activated PPAR?
Gene_expression (contains) of SSAT associated with colorectal cancer
10) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.40 Pain Relevance 0
Recently, Babbar et al. [5] demonstrated that in colorectal tumour cells, the promoter of spermidine/spermine N1-acetyltransferase (SSAT) gene contains a functional PPAR responsive element and activated PPAR?
Gene_expression (responsive) of SSAT associated with colorectal cancer
11) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.40 Pain Relevance 0
and SSAT expression as well as in SSAT activity.
Gene_expression (expression) of SSAT
12) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.57 Pain Relevance 0
restored the SSAT promoter activity, and an activated PPAR?
Gene_expression (activity) of SSAT promoter
13) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.48 Pain Relevance 0
SSAT activity was expressed as pmol of N1-[14C] acetylspermidine generated/min/mg of protein.


Gene_expression (expressed) of SSAT
14) Confidence 0.60 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.09 Pain Relevance 0
, ODC and SSAT gene expression
Gene_expression (expression) of SSAT gene
15) Confidence 0.60 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.55 Pain Relevance 0
and SSAT gene expression was observed in both normal and neoplastic tissue (r = 0.73, p < 0.0001; r = 0.65, p < 0.0001, respectively; Spearman correlation coefficient) (Figure 1).
Gene_expression (expression) of SSAT gene
16) Confidence 0.60 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.29 Pain Relevance 0
and the SSAT gene expression was observed in both normal and neoplastic tissue (r = 0.73, p < 0.0001; r = 0.65, p < 0.0001, respectively).
Gene_expression (expression) of SSAT gene
17) Confidence 0.60 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1543652 Disease Relevance 0.52 Pain Relevance 0
However, in a vitro study, it has been shown that mutated K-ras suppressed the SSAT expression via a transcriptional mechanism involving the PPAR?
Gene_expression (expression) of SSAT
18) Confidence 0.60 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.58 Pain Relevance 0
This also explains why the SAT is negative during the incubation period and following abortion [19].
Gene_expression (negative) of SAT associated with reprotox - general 1
19) Confidence 0.47 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2186323 Disease Relevance 0.67 Pain Relevance 0.10
expression, as well as ODC and SSAT mRNA levels were significantly higher (p < 0.05; Mann Whitney test) in colorectal carcinoma samples expressing K-ras mutation as compared to non mutated K-ras samples.
Gene_expression (expression) of SSAT mRNA associated with colorectal cancer
20) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.31 Pain Relevance 0

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