INT109415

Context Info Confidence 0.34 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.16 Pain Relevance 0.22

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 97.04 Inflammation 1 96.56 palliative 3 39.60 agonist 4 30.32 Pain 3 17.84 Analgesic 3 5.00 dexamethasone 2 5.00 Spinal cord 1 5.00 Angina 1 5.00 Intractable pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 36 100.00 Familial Adenomatous Polyposis 3 100.00 Renal Disease 20 99.34 INFLAMMATION 1 96.56 Breast Cancer 67 94.56 Pathologic Processes 1 89.00 Intestinal Cancer 2 75.00 Chronic Renal Failure 10 74.48 Colon Cancer 2 74.40 Hypertension 17 68.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The key question for future research on the matter should be: are results in CES or RAS improved by adding haptic feedback?

Negative_regulation (improved) of Positive_regulation (results) of RAS

1) Confidence 0.34 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Conversely, inhibition of Ras activation resulted in radiosensitization both in rodent cells transfected with Ras and in human tumor cells bearing endogenous mutations in Ras [26].

Negative_regulation (inhibition) of Positive_regulation (activation) of Ras associated with cancer

2) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.32 Pain Relevance 0

Farnesyl transferase inhibitors block the first and most important step in the activation of Ras signaling pathways [44].

Negative_regulation (block) of Positive_regulation (activation) of Ras

3) Confidence 0.05 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.24 Pain Relevance 0

Inactivation of the APC tumour-suppressor gene, and the activation of K-ras, have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines.

Negative_regulation (Inactivation) of Positive_regulation (activation) of ras associated with cancer and familial adenomatous polyposis

4) Confidence 0.05 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.73 Pain Relevance 0.22

Randomized controlled trials with agents that interrupt the renin-angiotensin-system (RAS) [3]–[5] have demonstrated a slowing of renal function decline in individuals with renal disease, providing strong evidence that activation of the RAS may promote a more rapid loss of GFR in patients with renal disease.

Negative_regulation (loss) of Positive_regulation (activation) of RAS associated with renal disease

5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.86 Pain Relevance 0

General Comments

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