INT109418

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

TP53TG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 84.24 Quite High
Angina 1 77.80 Quite High
Potency 4 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 127 98.36 Very High Very High Very High
Adrenal Cancer 1 95.44 Very High Very High Very High
Neuroblastoma 1 91.56 High High
Hypertension 2 78.48 Quite High
Angina 1 77.80 Quite High
Ganglioneuroma 2 75.00 Quite High
Neuroendocrine Cancer 1 75.00 Quite High
Diarrhoea 1 75.00 Quite High
Malignant Neoplastic Disease 2 74.12 Quite High
Ganglion Cysts 1 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further elucidate the histo- and pathogenesis of adrenal GN, we performed loss of heterozygosity studies on chromosomal loci 1p34-36 and 17p13 (the p53 gene locus) after careful microdissection of tumor and normal tissue.
Negative_regulation (loss) of p53 gene associated with cancer
1) Confidence 0.07 Published 2003 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12653673 Disease Relevance 1.02 Pain Relevance 0.12
On the other hand, Oct4/ATSC exhibited prominent p21 and p53 gene downregulation.
Negative_regulation (downregulation) of p53 gene
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.19 Pain Relevance 0
In humans, this complex leads to the inhibition of target gene protein translation and only very rarely causes degradation of the mRNA [33].
Negative_regulation (inhibition) of target gene
3) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0 Pain Relevance 0

General Comments

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