INT109430

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 119
Total Number 126
Disease Relevance 44.00
Pain Relevance 49.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 9
DRG 4
spinal 2
skin 2
urinary bladder 2
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 663 100.00 Very High Very High Very High
TRP channel 410 100.00 Very High Very High Very High
nociceptor 192 100.00 Very High Very High Very High
addiction 38 100.00 Very High Very High Very High
agonist 662 99.98 Very High Very High Very High
bradykinin 61 99.98 Very High Very High Very High
lidocaine 12 99.98 Very High Very High Very High
Inflammation 609 99.96 Very High Very High Very High
dorsal root ganglion 170 99.96 Very High Very High Very High
Pain 614 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 305 100.00 Very High Very High Very High
INFLAMMATION 638 99.96 Very High Very High Very High
Ganglion Cysts 405 99.96 Very High Very High Very High
Pain 642 99.92 Very High Very High Very High
Hyperalgesia 104 99.92 Very High Very High Very High
Neuropathic Pain 568 99.50 Very High Very High Very High
Stress 34 99.44 Very High Very High Very High
Inflammatory Pain 200 98.92 Very High Very High Very High
Hypersensitivity 652 98.56 Very High Very High Very High
Wound Healing 3 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that activation of spinal TRPA1 presynaptically facilitates miniature excitatory synaptic transmission from primary afferents onto vertical and radial cells to initiate action potentials.
Positive_regulation (activation) of TRPA1 in radial associated with action potential
1) Confidence 0.70 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20497466 Disease Relevance 0 Pain Relevance 0.82
In addition, the recovery of the epithelial wound was potently inhibited when the ambient temperature was lowered to 17 degrees C, the threshold temperature where TRPA1 is known to be activated.
Positive_regulation (activated) of TRPA1 associated with injury
2) Confidence 0.70 Published 2007 Journal Inflammopharmacology Section Abstract Doc Link 17943255 Disease Relevance 0.92 Pain Relevance 0.27
These results showed for the first time that the activation of TRPA1 inhibited the repair of the epithelial wound in the stomach, probably by the suppression of cell migration, and suggested the involvement of TRPA1 in the mechanism of gastric epithelial restitution.
Positive_regulation (activation) of TRPA1 in stomach associated with injury
3) Confidence 0.70 Published 2007 Journal Inflammopharmacology Section Abstract Doc Link 17943255 Disease Relevance 0.86 Pain Relevance 0.27
Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer.
Positive_regulation (activation) of TRPA1 associated with qutenza and injury
4) Confidence 0.70 Published 2007 Journal Inflammopharmacology Section Title Doc Link 17943255 Disease Relevance 0.64 Pain Relevance 0.16
These results indicate that lidocaine activates TRPA1 in nerve terminals presynaptic to SG neurons to increase the spontaneous release of L-glutamate.
Positive_regulation (activates) of TRPA1 in neurons associated with substantia gelatinosa, glutamate and lidocaine
5) Confidence 0.69 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19135979 Disease Relevance 0 Pain Relevance 1.09
TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase.
Positive_regulation (activation) of TRPA1 in nerve associated with glutamate and lidocaine
6) Confidence 0.69 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 19135979 Disease Relevance 0 Pain Relevance 1.08
Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated by the pungent compounds present in spices.
Positive_regulation (activated) of TRPA1
7) Confidence 0.69 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838811 Disease Relevance 0 Pain Relevance 0.17
CONCLUSIONS: The activation of TRPA1 in DRG neurons by noxious GD may be involved in acute visceral pain.
Positive_regulation (activation) of TRPA1 in DRG
8) Confidence 0.69 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.06 Pain Relevance 0
We conclude that, via generation of reactive oxygen species, light-induced TRPA1 activation provides an additional mode of activation, which renders TRPA1 a likely molecular candidate in processes leading to painful or burning sensations during photodynamic therapy or upon local application of hydrogen peroxide.
Positive_regulation (activation) of TRPA1 associated with pain
9) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.10
Accordingly, hydrogen peroxide induced a TRPA1 activation with a membrane-delimited mode of action that was attenuated by dithiothreitol.
Positive_regulation (activation) of TRPA1
10) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.13 Pain Relevance 0.12
Since extracellular application of hydrogen peroxide mimicked the effect of UVA irradiation and since dithiothreitol partly reversed the activation by UVA exposure, we conclude that reactive oxygen species may mediate the light-induced activation of TRPA1.
Positive_regulation (activation) of TRPA1
11) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.14 Pain Relevance 0.12
In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.
Positive_regulation (activation) of TRPA1
12) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.15 Pain Relevance 0.07
Intracellular but not extracellular application of FeSO(4), which catalyses the formation of highly reactive hydroxyl radicals potentiated the hydrogen peroxide-stimulated TRPA1 activation.
Positive_regulation (activation) of TRPA1
13) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.08
Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress.
Positive_regulation (activate) of TRPA1 associated with stress
14) Confidence 0.69 Published 2009 Journal Cell Calcium Section Title Doc Link 18814910 Disease Relevance 0.19 Pain Relevance 0.09
There are several factors that may contribute to the lowering of mechanical thresholds for TRPA1-containing neurons after CFA injection, including TRPA1 upregulation in the dorsal root ganglion [17,18], and direct activation or indirect sensitization of the receptor by bradykinin, prostaglandins, and other endogenous agents released during inflammation [8,10,28-32].
Positive_regulation (upregulation) of TRPA1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, inflammation and bradykinin
15) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.77 Pain Relevance 0.53
In the present study, we examined whether activation of the TRPA1 channels affects synaptic transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique.
Spec (whether) Positive_regulation (activation) of TRPA1 in neurons associated with substantia gelatinosa and spinal cord
16) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17442829 Disease Relevance 0 Pain Relevance 0.34
Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Positive_regulation (Activation) of TRPA1 in substantia gelatinosa associated with substantia gelatinosa neuron and spinal cord
17) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Title Doc Link 17442829 Disease Relevance 0 Pain Relevance 0.40
Two studies suggested that calcium may directly activate the channel by binding to the EF-hand domain, a prerequisite for icilin activation of TRPA1 [20,21].
Positive_regulation (activation) of TRPA1
18) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.75 Pain Relevance 0.54
Controversy around the apparent promiscuous activation of TRPA1 by structurally unrelated compounds was diminished by the finding that the majority of TRPA1 activators gate the channel through chemical reactivity of their electrophilic groups with some of the nucleophilic cysteine residues at the N-terminus of the channel [18,19].
Positive_regulation (activation) of TRPA1
19) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.51 Pain Relevance 0.36
We show that this compound selectively inhibited human TRPA1 activation by cinnamaldehyde with an IC50 of 4.9 ?
Positive_regulation (activation) of TRPA1
20) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.79 Pain Relevance 0.63

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