INT109431

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 5
Speculated 5
Reported most in Body
Documents 123
Total Number 130
Disease Relevance 51.84
Pain Relevance 59.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 19
sensory neurons 9
DRG 9
nociceptors 5
skin 4
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1551 100.00 Very High Very High Very High
agonist 1283 100.00 Very High Very High Very High
qutenza 866 100.00 Very High Very High Very High
Pain 574 100.00 Very High Very High Very High
nociceptor 551 100.00 Very High Very High Very High
antagonist 324 100.00 Very High Very High Very High
bradykinin 57 100.00 Very High Very High Very High
substance P 37 100.00 Very High Very High Very High
Calcitonin gene-related peptide 36 100.00 Very High Very High Very High
dorsal root ganglion 241 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1625 100.00 Very High Very High Very High
Nociception 527 100.00 Very High Very High Very High
Ganglion Cysts 451 99.96 Very High Very High Very High
Hyperalgesia 190 99.60 Very High Very High Very High
Camurati-engelmann Disease 48 99.60 Very High Very High Very High
Pain 581 99.56 Very High Very High Very High
Injury 100 99.48 Very High Very High Very High
Neuropathic Pain 493 99.18 Very High Very High Very High
Inflammatory Pain 102 99.00 Very High Very High Very High
Nervous System Injury 102 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mustard oil [allyl isothiocyanate (AITC)] and cinnamaldehyde (CA), agonists of the ion channel TRPA1 expressed in sensory neurons, elicit a burning sensation and heat hyperalgesia.
Gene_expression (expressed) of TRPA1 in sensory neurons associated with hyperalgesia and agonist
1) Confidence 0.78 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 17942619 Disease Relevance 0.10 Pain Relevance 0.19
TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord.
Gene_expression (expressing) of TRPA1 in spinal cord associated with qutenza, substantia gelatinosa neuron and spinal cord
2) Confidence 0.78 Published 2010 Journal Eur. J. Neurosci. Section Title Doc Link 20497466 Disease Relevance 0.18 Pain Relevance 0.76
METHODS: Quantitative reverse transcriptase-polymerase chain reaction and immunofluorescent staining was used to investigate the expression of TRPA1 in primary sensory neurons innervating the rat bladder.
Spec (investigate) Gene_expression (expression) of TRPA1 in bladder
3) Confidence 0.78 Published 2007 Journal Urology Section Body Doc Link 17991581 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: TRPA1 is expressed in the bladder-innervating primary sensory neurons.
Gene_expression (expressed) of TRPA1 in primary sensory neurons
4) Confidence 0.78 Published 2007 Journal Urology Section Body Doc Link 17991581 Disease Relevance 0 Pain Relevance 0
TRPV1 is mainly expressed in the sensory neurons and coexpressed with TRPA1 at a high frequency.
Gene_expression (coexpressed) of TRPA1 in sensory neurons
5) Confidence 0.78 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838811 Disease Relevance 0 Pain Relevance 0.24
Here, we investigated the expression of TRPA1 in primary sensory afferents and its involvement in visceral hypersensitivity in rats.
Spec (investigated) Gene_expression (expression) of TRPA1 in visceral associated with nud
6) Confidence 0.78 Published 2009 Journal Gut Section Abstract Doc Link 19515638 Disease Relevance 0.19 Pain Relevance 0.36
RESULTS: TRPA1 was predominantly expressed with sensory neuropeptides in DRG and NG neurons, and in nerve fibres in the rat stomach.
Gene_expression (expressed) of TRPA1 in DRG
7) Confidence 0.78 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.09 Pain Relevance 0
METHODS: We examined TRPA1 expression in the dorsal root ganglion (DRG), nodose ganglion (NG), and stomach of rats by using immunohistochemistry.
Spec (examined) Gene_expression (expression) of TRPA1 in ganglion
8) Confidence 0.78 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.10 Pain Relevance 0
TRPA1, a Ca(2+)-permeable cation channel that is expressed in sensory neurones, is involved in the perception of chemical irritants and mechanical hyperalgesia.
Gene_expression (expressed) of TRPA1 associated with hyperalgesia
9) Confidence 0.77 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.17 Pain Relevance 0.10
After an inflammatory injury, there is an increase in TRPA1 expression as well as a decrease in mechanical thresholds of TRPA1-containing primary afferent neurons [17,18].
Gene_expression (expression) of TRPA1 in afferent neurons associated with inflammation and injury
10) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.49 Pain Relevance 0.48
Since A-967079 was administered systemically we cannot determine its exact site(s) of action, but expression of TRPA1 has been localized to different sized primary afferent sensory neurons as well as epidermal kerantinocytes [4-8].
Gene_expression (expression) of TRPA1 in sensory neurons
11) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.50 Pain Relevance 0.41
TRPA1 is expressed in primary sensory neurons and hair cells, and it is proposed to be activated by cold stimuli, mechanical stimuli, or pungent ingredients.
Gene_expression (expressed) of TRPA1 in primary sensory neurons
12) Confidence 0.77 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17442829 Disease Relevance 0 Pain Relevance 0.18
Furthermore, transfecting ND-C cells with the candidate mechanotransducer channel TRPA1 does not increase MA current amplitudes, despite TRPA1 being functionally expressed at the plasma membrane.
Gene_expression (expressed) of TRPA1 in plasma
13) Confidence 0.77 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19348834 Disease Relevance 0 Pain Relevance 0.17
Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.
Gene_expression (Expression) of TRPA1 in spinal associated with nociceptor and spinal dorsal horn
14) Confidence 0.77 Published 2010 Journal J. Comp. Neurol. Section Title Doc Link 20034057 Disease Relevance 0.42 Pain Relevance 0.79
In the TG, TRPA1 was expressed in unmyelinated and small myelinated axons and also occasionally in large myelinated axons.
Gene_expression (expressed) of TRPA1 associated with trigeminal ganglion and unmyelinated
15) Confidence 0.77 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 20034057 Disease Relevance 0.45 Pain Relevance 0.44
HEK-293 cells stably expressing human TRPA1 were plated into 384-well plates at a density of 20,000 cells/well 24 hours prior to assaying.
Gene_expression (expressing) of TRPA1
16) Confidence 0.77 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.34 Pain Relevance 0.27
Another possibility is the potential embryonic rewiring of the neuronal circuitries expressing TRPA1 possibly masking the phenotype.
Gene_expression (expressing) of TRPA1 in neuronal
17) Confidence 0.77 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 1.01 Pain Relevance 0.44
Although some reports suggested that cold hypersensitivity in chronic inflammatory or neuropathic pain might be associated with an increase in TRPA1 expression (Obata et al., 2005; Ji et al., 2008), this has been recently contested (Caspani et al., 2007).
Gene_expression (expression) of TRPA1 associated with inflammation, hypersensitivity and neuropathic pain
18) Confidence 0.77 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.57 Pain Relevance 0.37
The slow heat ramps used in these studies preferentially activate C fibre nociceptors expressing TRPV1 (McMullan et al., 2004), many of which also express TRPA1 (Story et al., 2003; Dunham et al., 2008).
Gene_expression (express) of TRPA1 in nociceptors associated with c fibre and nociceptor
19) Confidence 0.77 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0 Pain Relevance 0.71
Interpretation of these findings may be complicated by the observation of TRPA1 expression in spinal motoneurones and skin (Anand et al., 2008; Atoyan et al., 2009).
Gene_expression (expression) of TRPA1 in skin
20) Confidence 0.77 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox