INT109432

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 7.01
Pain Relevance 8.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
spinal cord 2
brain 2
fibroblasts 2
DRG 2
microglia 2
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperesthesia 6 100.00 Very High Very High Very High
dorsal root ganglion 6 99.80 Very High Very High Very High
Hippocampus 12 99.76 Very High Very High Very High
agonist 204 99.26 Very High Very High Very High
Spinal cord 6 98.76 Very High Very High Very High
Inflammation 116 98.72 Very High Very High Very High
Neuropathic pain 4 98.52 Very High Very High Very High
transcutaneous nerve stimulation 14 98.44 Very High Very High Very High
intrathecal 6 98.04 Very High Very High Very High
gABA 12 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 99.80 Very High Very High Very High
INFLAMMATION 129 98.72 Very High Very High Very High
Neuropathic Pain 8 98.52 Very High Very High Very High
Nervous System Injury 4 97.52 Very High Very High Very High
Hyperalgesia 18 97.20 Very High Very High Very High
Injury 10 95.16 Very High Very High Very High
Pain 22 90.04 High High
Kaposis Sarcoma 3 89.76 High High
Rheumatoid Arthritis 58 88.88 High High
Frailty 2 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of ERK1/2 and MSK-1 was dose-dependently blocked by SCH23390, but not by raclopride.
Negative_regulation (blocked) of Phosphorylation (Phosphorylation) of ERK1/2
1) Confidence 0.54 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
These results suggest that down-regulation of ERK2 phosphorylation and c-Fos expression were involved in TENS inhibition on CFA-induced thermal hyperalgesia of rats.
Negative_regulation (down) of Phosphorylation (phosphorylation) of ERK2 associated with thermal hyperalgesia and transcutaneous nerve stimulation
2) Confidence 0.43 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.71 Pain Relevance 1.20
These results suggest that down-regulation of ERK2 phosphorylation and c-Fos expression were involved in TENS inhibition on CFA-induced thermal hyperalgesia of rats.
Negative_regulation (regulation) of Phosphorylation (phosphorylation) of ERK2 associated with thermal hyperalgesia and transcutaneous nerve stimulation
3) Confidence 0.43 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.71 Pain Relevance 1.19
Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats.
Negative_regulation (Attenuating) of Phosphorylation (phosphorylation) of p38 MAPK in microglia associated with hyperesthesia, brush evoked pain, eae, injury, lidocaine and intrathecal
4) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18191894 Disease Relevance 0.67 Pain Relevance 1.55
In this study, we demonstrate that attenuating phosphorylation of p38 MAPK in the activated microglia of spinal cord, at least partly, is the mechanism of intrathecal lidocaine reversing established tactile allodynia in chronic constriction injury model of rats.
Negative_regulation (attenuating) of Phosphorylation (phosphorylation) of p38 MAPK in spinal cord associated with brush evoked pain, eae, injury, lidocaine, intrathecal and spinal cord
5) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18191894 Disease Relevance 0.71 Pain Relevance 1.32
To further confirm the decrease in ERK1/2 phosphorylation, we also assessed their activity in response to PGF2?
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of ERK1/2
6) Confidence 0.41 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
-induced phosphorylation of ERK1/2 was decreased (Fig. 3C and 3D, lower panel).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK1/2
7) Confidence 0.41 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
The prevention of cholinergic cell loss by rofecoxib occurred concomitantly with the inhibition of p38MAPK phosphorylation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of p38MAPK
8) Confidence 0.34 Published 2003 Journal Neuroscience Section Abstract Doc Link 12654342 Disease Relevance 0.28 Pain Relevance 0.11
Our findings suggest an important role of brain inflammatory reaction in cholinergic degeneration and demonstrate a neuroprotective effect of rofecoxib, presumably mediated through the inhibition of p38MAPK phosphorylation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of p38MAPK in brain associated with inflammation
9) Confidence 0.34 Published 2003 Journal Neuroscience Section Abstract Doc Link 12654342 Disease Relevance 0.17 Pain Relevance 0.09
Western blotting analysis of DRG extracts detected phosphorylation of ERK1 and ERK2 (extracellular signal-regulated kinases) that peaked 10 min after exposure to 17beta-estradiol.
Negative_regulation (detected) of Phosphorylation (phosphorylation) of ERK2 in DRG associated with dorsal root ganglion
10) Confidence 0.33 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.87 Pain Relevance 0.34
The phosphorylation of ERK1/2 decreased after the MTBE injection.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK1/2
11) Confidence 0.32 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19344668 Disease Relevance 0.40 Pain Relevance 0.45
Furthermore, the decreased ability of learning and the reduction of phosphorylated ERK1/2 level of the MTBE-treated rats was partly reversed by bicuculline injected 30 min before the training.
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of ERK1/2
12) Confidence 0.32 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19344668 Disease Relevance 0.38 Pain Relevance 0.44
Furthermore, the decreased ability of learning and the reduction of phosphorylated ERK1/2 level of the MTBE-treated rats was partly reversed by bicuculline injected 30 min before the training.
Negative_regulation (reversed) of Phosphorylation (phosphorylated) of ERK1/2
13) Confidence 0.32 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19344668 Disease Relevance 0.38 Pain Relevance 0.45
In polarized CaCo2 cells, application of PC either from the apical or basolateral site inhibited the phosphorylation and activation of the MAP kinases p38, ERK1 and ERK2.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of ERK2
14) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.45 Pain Relevance 0.30
In our experimental system, the MEK1 inhibitor PD-98059 reproduced the suppressive effect of ATRA on IL-6 at a concentration actively preventing the phosphorylation of ERK1/2.
Negative_regulation (preventing) of Phosphorylation (phosphorylation) of ERK1/2 associated with agonist
15) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.25 Pain Relevance 0.47
Only recently the opposing phenotypic outcome of NGF and EGF signalling was correlated to a differential stimulation kinetic of Erk1/2 phosphorylation induced by NGF and EGF.
Negative_regulation (kinetic) of Phosphorylation (phosphorylation) of Erk1/2
16) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.19 Pain Relevance 0
Western blots were used to evaluate phosphorylation and activation of ERK1/2 and transcription factors using phospho-specific or total antibodies.
Negative_regulation (evaluate) of Phosphorylation (phosphorylation) of ERK1/2
17) Confidence 0.06 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.50 Pain Relevance 0.32
In addition, our data suggest that the suppressive effect of ATRA on these transcription factors may be supported by inhibition of ERK1/2 phosphorylation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of ERK1/2 associated with agonist
18) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.18 Pain Relevance 0.23
In contrast, we showed that phosphorylation of ERK1/2 was an early IL-1-mediated event in rat synovial fibroblasts and demonstrated that it was reduced significantly by ATRA.
Negative_regulation (event) of Phosphorylation (phosphorylation) of ERK1/2 in fibroblasts associated with agonist
19) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.17 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox