INT109434

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Context Info
Confidence 0.82
First Reported 2001
Last Reported 2010
Negated 8
Speculated 6
Reported most in Body
Documents 110
Total Number 144
Disease Relevance 61.64
Pain Relevance 34.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
thoracic aorta 16
kidney cortex 10
neurons 10
hippocampus 6
kidney medulla 6
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 105 100.00 Very High Very High Very High
Dismenorea 20 99.82 Very High Very High Very High
Hippocampus 457 99.76 Very High Very High Very High
Hyperesthesia 6 99.76 Very High Very High Very High
agonist 538 99.74 Very High Very High Very High
medulla 878 99.72 Very High Very High Very High
Spinal cord 510 99.68 Very High Very High Very High
dorsal root ganglion 38 99.64 Very High Very High Very High
Potency 39 99.60 Very High Very High Very High
Pain 1241 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 20 99.82 Very High Very High Very High
Diabetes Mellitus 5412 99.72 Very High Very High Very High
Ganglion Cysts 43 99.64 Very High Very High Very High
Hyperglycemia 289 99.62 Very High Very High Very High
Pain 1555 99.56 Very High Very High Very High
Nervous System Injury 34 99.44 Very High Very High Very High
Spinal Injuries 6 99.44 Very High Very High Very High
Hyperalgesia 540 99.36 Very High Very High Very High
Stress 330 99.32 Very High Very High Very High
Pheochromocytoma 30 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcutaneous electrical nerve stimulation on Yongquan acupoint reduces CFA-induced thermal hyperalgesia of rats via down-regulation of ERK2 phosphorylation and c-Fos expression.
Phosphorylation (phosphorylation) of ERK2 in nerve associated with thermal hyperalgesia and transcutaneous nerve stimulation
1) Confidence 0.82 Published 2010 Journal Anat Rec (Hoboken) Section Title Doc Link 20583264 Disease Relevance 0.72 Pain Relevance 1.03
These results suggest that down-regulation of ERK2 phosphorylation and c-Fos expression were involved in TENS inhibition on CFA-induced thermal hyperalgesia of rats.
Phosphorylation (phosphorylation) of ERK2 associated with thermal hyperalgesia and transcutaneous nerve stimulation
2) Confidence 0.82 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.70 Pain Relevance 1.16
We found that CFA injection caused an area of localized swelling, erythema, hypersensitivity to thermal stimuli, the decreased response time of hind paw licking (HPL), as well as upregulation of c-Fos protein expression and ERK2 phosphorylation in the ipsilateral spinal dorsal horn and the contralateral primary somatosensory area of cortex and the amygdala of rats.
Phosphorylation (phosphorylation) of ERK2 in dorsal horn associated with pressure and volume under development, erythema, spinal dorsal horn, hypersensitivity and amygdala
3) Confidence 0.82 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.76 Pain Relevance 1.24
In this study, we demonstrate that attenuating phosphorylation of p38 MAPK in the activated microglia of spinal cord, at least partly, is the mechanism of intrathecal lidocaine reversing established tactile allodynia in chronic constriction injury model of rats.
Phosphorylation (phosphorylation) of p38 MAPK in spinal cord associated with brush evoked pain, eae, injury, lidocaine, intrathecal and spinal cord
4) Confidence 0.81 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18191894 Disease Relevance 0.71 Pain Relevance 1.32
Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats.
Phosphorylation (phosphorylation) of p38 MAPK in microglia associated with hyperesthesia, brush evoked pain, eae, injury, lidocaine and intrathecal
5) Confidence 0.81 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18191894 Disease Relevance 0.67 Pain Relevance 1.55
To investigate the functional roles of Gi2 on ERK1/2 activation, we examined the phosphorylation of ERK1/2 in ribozyme-treated cells following PGF2?
Spec (examined) Phosphorylation (phosphorylation) of ERK1/2
6) Confidence 0.78 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
The basal level of ERK1/2 phosphorylation (i.e. in the absence PGF2?
Phosphorylation (phosphorylation) of ERK1/2
7) Confidence 0.78 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the hippocampus
Phosphorylation (phosphorylation) of ERK2 in hippocampus associated with hippocampus
8) Confidence 0.78 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.38 Pain Relevance 0.29
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the S1 area
Phosphorylation (phosphorylation) of ERK2
9) Confidence 0.78 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.25 Pain Relevance 0.44
g cell protein (total cell lysate prepared in Laemmli buffer) were electrophoresed on 10 % polyacrylamide gels (acrylamide:N'N'-bis-methylene acrylamide 30:0.8) followed by protein electrotransfer to nitrocellulose membranes and immunoblotting with a polyclonal MAP kinase antibody against the dually threonine- and tyrosine phosphorylated forms of ERK1 (p44mapk) and ERK2 (p42mapk) or an antibody detecting both the phosphorylated and unphosphorylated forms (Promega Corporation, Madison, WI, USA).
Phosphorylation (phosphorylated) of ERK2 in g cell
10) Confidence 0.78 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0.03
g cell protein (total cell lysate prepared in Laemmli buffer) were electrophoresed on 10 % polyacrylamide gels (acrylamide:N'N'-bis-methylene acrylamide 30:0.8) followed by protein electrotransfer to nitrocellulose membranes and immunoblotting with a polyclonal MAP kinase antibody against the dually threonine- and tyrosine phosphorylated forms of ERK1 (p44mapk) and ERK2 (p42mapk) or an antibody detecting both the phosphorylated and unphosphorylated forms (Promega Corporation, Madison, WI, USA).
Phosphorylation (phosphorylated) of p42mapk in g cell
11) Confidence 0.78 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0.03
In an attempt to unmask the state-dependent changes in the phosphorylation and total expression of ERK1 and ERK2 and hence illustrate the potential influences of pain-related behavioral consequence on ERK-mediated intracellular signaling pathways, we tested the temporal alterations in both pERK1/2 and tERK1/2 after s.c. saline or bee venom injection.
Phosphorylation (phosphorylation) of ERK2 associated with pain
12) Confidence 0.77 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.36 Pain Relevance 0.40
Phosphorylated ERK1/2 is localized to both dynorphinergic and enkephalinergic striatal neurons, suggesting a general role of ERK1/2 as a plasticity molecule during L-DOPA treatment.


Phosphorylation (Phosphorylated) of ERK1/2 in neurons
13) Confidence 0.76 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
RESULTS: L-DOPA treatment caused phosphorylation of ERK1/2 in the dopamine-denervated striatum after acute and chronic administration.
Phosphorylation (phosphorylation) of ERK1/2 in striatum
14) Confidence 0.76 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
Phosphorylation of ERK1/2 and MSK-1 was dose-dependently blocked by SCH23390, but not by raclopride.
Phosphorylation (Phosphorylation) of ERK1/2
15) Confidence 0.76 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
Phosphorylation of ERK1/2, mitogen- and stress-activated protein kinase-1 (MSK-1), and the levels of FosB/DeltaFosB expression were examined immunohistochemically.
Spec (examined) Phosphorylation (Phosphorylation) of ERK1/2
16) Confidence 0.76 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17662258 Disease Relevance 0 Pain Relevance 0
Compared with adult (6-month) and aged (27-month) rats, very aged rats (33-month) had higher levels of blood glucose, phosphorylation of soleus p38-MAPK and extracellular-regulated kinase 1/2 (ERK1/2), superoxide and oxidatively modified proteins (p<0.05), and these changes were associated with decreased soleus Glut4 protein abundance (p<0.05).
Phosphorylation (phosphorylation) of p38-MAPK in blood
17) Confidence 0.70 Published 2009 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 19177471 Disease Relevance 0 Pain Relevance 0
We employed inhibitors and activators of protein kinase A (PKA), protein kinase C (PKC), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and calcium/calmodulin-dependent kinase II (CaMKII) to examine whether these kinases individually or in concert mediate the increase in CREB phosphorylation that is evident as early as 2 h after loose ligation of the sciatic nerve.
Phosphorylation (inhibitors) of extracellular signal-regulated kinase 1 and 2 in sciatic nerve associated with kinase c and sciatic nerve
18) Confidence 0.68 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.20 Pain Relevance 0.41
Cells treated with 2,2'-DCB increased phosphorylated MAPK1, implicating the increase of activation of MAPK1.
Phosphorylation (hosphorylated ) of MAPK1
19) Confidence 0.68 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.22 Pain Relevance 0.29
Therefore, this study suggests that 2,2'-DCB decreases amplitude and synchronization of uterine contractions mediated through MAPK1-mediated phosphorylation of GJA1 and subsequent inhibition of myometrial gap junctions.
Phosphorylation (phosphorylation) of MAPK1 in uterine associated with dismenorea
20) Confidence 0.67 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.27 Pain Relevance 0.27

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