INT109444

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
neurons 1
Kcnk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 9 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
cocaine 2 99.54 Very High Very High Very High
Morphine 7 99.40 Very High Very High Very High
opioid receptor 9 98.40 Very High Very High Very High
Opioid 1 95.32 Very High Very High Very High
addiction 1 93.20 High High
Neurotransmitter 1 91.48 High High
opiate 1 84.92 Quite High
Delta opioid receptors 1 75.00 Quite High

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of delta-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons.
Positive_regulation (activation) of D1R in neurons associated with dopamine, opioid receptor and cocaine
1) Confidence 0.17 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.66
RESULTS: After one injection, changes that were specific to U69593/QNP cotreatment were decreased D1R and D2R messenger RNA (mRNA) in the nucleus accumbens (Acb) shell and increased DYN mRNA in the dorsal striatum (STR).
Positive_regulation (decreased) of D1R in nucleus accumbens
2) Confidence 0.01 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17619861 Disease Relevance 0 Pain Relevance 0
Tissues were assayed for D1, D2 and D3 dopamine receptor mRNAs (D1R, D2R and D3R), as well as for mRNAs for tyrosine hydroxylase (TH) and the dopamine transporter (DAT).
Positive_regulation (assayed) of D1R associated with dopamine and dopamine receptor
3) Confidence 0.01 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox