INT109444

Context Info Confidence 0.17 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 1.37

Anatomy Link Frequency nucleus accumbens 1 neurons 1 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 9 100.00 dopamine receptor 2 100.00 cocaine 2 99.54 Morphine 7 99.40 opioid receptor 9 98.40 Opioid 1 95.32 addiction 1 93.20 Neurotransmitter 1 91.48 opiate 1 84.92 Delta opioid receptors 1 75.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of delta-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons.

Positive_regulation (activation) of D1R in neurons associated with dopamine, opioid receptor and cocaine

1) Confidence 0.17 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.66

RESULTS: After one injection, changes that were specific to U69593/QNP cotreatment were decreased D1R and D2R messenger RNA (mRNA) in the nucleus accumbens (Acb) shell and increased DYN mRNA in the dorsal striatum (STR).

Positive_regulation (decreased) of D1R in nucleus accumbens

2) Confidence 0.01 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17619861 Disease Relevance 0 Pain Relevance 0

Tissues were assayed for D1, D2 and D3 dopamine receptor mRNAs (D1R, D2R and D3R), as well as for mRNAs for tyrosine hydroxylase (TH) and the dopamine transporter (DAT).

Positive_regulation (assayed) of D1R associated with dopamine and dopamine receptor

3) Confidence 0.01 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.72

General Comments

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