INT109448

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.62
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
MTHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 359 98.14 Very High Very High Very High
methotrexate 39 93.28 High High
excitatory amino acid 3 89.72 High High
rheumatoid arthritis 63 85.92 High High
headache 73 75.68 Quite High
Pain 2 71.56 Quite High
Inflammation 75 61.92 Quite High
Bioavailability 3 53.12 Quite High
adenocard 3 41.16 Quite Low
chemokine 3 32.00 Quite Low
Disease Link Frequency Relevance Heat
Stroke 26 99.82 Very High Very High Very High
Colon Cancer 297 99.56 Very High Very High Very High
Hyperhomocysteinemia 9 99.24 Very High Very High Very High
Headache 407 98.14 Very High Very High Very High
Cancer 49 97.92 Very High Very High Very High
Toxicity 10 97.44 Very High Very High Very High
Hypertension 8 96.52 Very High Very High Very High
Migraine With Aura 153 96.32 Very High Very High Very High
Increased Venous Pressure Under Development 15 95.92 Very High Very High Very High
Thrombosis 3 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, all three migraine association studies of the C677T variant show a similar overall trend, and interpreted together, provide compelling evidence that the homozygous T/T genotype of the MTHFR gene, perhaps leading to reduced MTHFR enzyme activity and mild hyperhomocysteinemia, increases susceptibility to migraine, particularly MA.
Negative_regulation (reduced) of MTHFR enzyme associated with migraine with aura, migraine and hyperhomocysteinemia
1) Confidence 0.58 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 1.26 Pain Relevance 0.59
Individuals with the Val residue may exhibit significantly reduced MTHFR enzyme activity whereby, compared to baseline levels, the mean activity is 65% in the Ala/Val heterozygote and 30% in the Val/Val homozygous state [16].
Negative_regulation (reduced) of MTHFR enzyme
2) Confidence 0.58 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 0.40 Pain Relevance 0.16
Although controversial, diminished activity of 5,10 methylenetetrahydrofolate reductase (MTHFR), a regulatory enzyme of homocysteine metabolism, may predispose to migraine in Turkish people.
Negative_regulation (diminished) of MTHFR associated with migraine
3) Confidence 0.57 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654508 Disease Relevance 0.55 Pain Relevance 0.55
Individuals carrying the C677T variant in the MTHFR gene have been shown to have decreased MTHFR enzyme activity, and the TT genotype is indirectly linked to mild hyperhomocystinemia possibly resulting in vascular disease.
Negative_regulation (decreased) of MTHFR enzyme associated with increased venous pressure under development
4) Confidence 0.56 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.37 Pain Relevance 0.49
When folate levels are adequate, the reduced MTHFR activity induced by the same genotypes would lead to a great pool of methylenetetrahydrofolate available for DNA synthesis, and therefore prevent cancer by diminishing uracil misincorporation.
Negative_regulation (reduced) of MTHFR associated with cancer
5) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.67 Pain Relevance 0.06
The atherothrombotic effects of hyperhomocystinemia have been postulated to increase the risk of stroke and the decrease in MTHFR activity due to C677T mutation, affecting DNA repair and cell division, may result in hypertension [12].
Negative_regulation (decrease) of MTHFR associated with stroke and hypertension
6) Confidence 0.48 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 0.95 Pain Relevance 0.17
Two polymorphisms c.665C>T (also reported as C677T) and c.1286A>C (aka c.1298A>C), have been widely tested for modification of CRC risk, because of the reduction in MTHFR activity induced by their minor allele.
Negative_regulation (reduction) of MTHFR associated with colon cancer
7) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.49 Pain Relevance 0.03
Mu et al. suggested indeed that genotypes reducing MTHFR activity – here c.1286CC or c.1286AC – would favor cancer risk when dietary folate levels are low, by inducing a DNA hypomethylation causing DNA damage and mutations [56].
Negative_regulation (reducing) of MTHFR associated with cancer
8) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.50 Pain Relevance 0
The presence of the T allele was associated with the largest number of migraine symptoms and triggers, suggesting that although the TT genotype appears to have a recessive effect on MTHFR enzyme levels, perhaps both heterozygous and homozygous states of the T allele may contribute to the phenotypic expression of migraine.
Negative_regulation (effect) of MTHFR enzyme associated with migraine
9) Confidence 0.40 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 0.88 Pain Relevance 0.62
The A1298C polymorphism also results in decreased MTHFR activity and exhibits other discrepancies in its clinical effects.
Negative_regulation (decreased) of MTHFR
10) Confidence 0.28 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.54 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox