INT109470

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.13
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) signal transduction (ITK) cytoplasm (ITK)
Anatomy Link Frequency
sperm 1
ITK (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 1 100.00 Very High Very High Very High
fluoxetine 2 95.96 Very High Very High Very High
Desipramine 2 95.36 Very High Very High Very High
5HT 8 92.48 High High
antagonist 1 88.68 High High
Serotonin 2 85.44 High High
Cannabinoid receptor 5 81.04 Quite High
Endocannabinoid 5 78.92 Quite High
methotrexate 3 47.20 Quite Low
qutenza 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 27 99.56 Very High Very High Very High
Capsule Opacification 171 98.64 Very High Very High Very High
Cataract 93 96.92 Very High Very High Very High
Retina Disease 9 89.84 High High
Endophthalmitis 6 88.88 High High
Sperm Disorder 1 87.92 High High
Macular Edema 6 85.68 High High
Postoperative Complications 6 83.64 Quite High
Reprotox - General 1 2 78.76 Quite High
INFLAMMATION 12 15.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitors of the extraneuronal monoamine transporter (EMT) and of the organic cation transporter type 2 (OCT2), corticosterone and decynium22, had no effect on (3)H-MPP(+) specific uptake, but cyanine863 concentration-dependently reduced it (with an IC(50) of 23 microM ).
Negative_regulation (inhibitors) of EMT associated with monoamine
1) Confidence 0.24 Published 2003 Journal Placenta Section Abstract Doc Link 12657510 Disease Relevance 0.15 Pain Relevance 0.66
The development of alternative methods to prevent PCO is therefore of critical importance, and a pharmacologic method of inhibiting LEC EMT and proliferation would contribute markedly to the success of extracapsular cataract extraction with IOL placement.
Negative_regulation (inhibiting) of EMT associated with capsule opacification and cataract
2) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 1.22 Pain Relevance 0
The sperm exposure to OMDM-1, a specific inhibitor of EMT, prevented the promoting effect of CPZ on spontaneous AR rate and restored the sperm responsiveness to P.
Negative_regulation (inhibitor) of EMT in sperm
3) Confidence 0.12 Published 2009 Journal Endocrinology Section Abstract Doc Link 19608651 Disease Relevance 0.09 Pain Relevance 0.30
As shown previously, EMT was inhibited when LEC were incubated in either rofecoxib or celecoxib during the first week of culture.
Negative_regulation (inhibited) of EMT
4) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0 Pain Relevance 0
However, inhibition of EMT by the drugs appeared to be irreversible.


Negative_regulation (inhibition) of EMT
5) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.67 Pain Relevance 0

General Comments

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