INT109476

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.90
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UGT1A7) enzyme binding (UGT1A7)
Anatomy Link Frequency
liver 1
pancreas 1
UGT1A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 93.16 High High
Paracetamol 1 69.84 Quite High
Codeine 1 68.64 Quite High
carbamazepine 1 66.96 Quite High
Chronic pancreatitis 4 50.00 Quite Low
Potency 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperbilirubinemia 21 98.72 Very High Very High Very High
Toxicity 4 97.08 Very High Very High Very High
Pancreatitis 6 83.44 Quite High
Syndrome 2 79.60 Quite High
Jaundice 6 74.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 61 51.04 Quite High
Pancreatic Cancer 2 50.00 Quite Low
Disorder Of Lipid Metabolism 15 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Lipodystrophy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Predominant expression of the UGT1A7 gene was identified in human pancreatic tissue.
Gene_expression (expression) of UGT1A7
1) Confidence 0.78 Published 2003 Journal Gastroenterology Section Body Doc Link 12806614 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: The UGT1A7 gene is predominantly expressed in human pancreas.
Gene_expression (expressed) of UGT1A7 in pancreas
2) Confidence 0.78 Published 2003 Journal Gastroenterology Section Body Doc Link 12806614 Disease Relevance 0.05 Pain Relevance 0
Several others (e.g., UGT1A7, UGT1A8, and UGT1A10) are expressed only in extrahepatic tissues.
Gene_expression (expressed) of UGT1A7
3) Confidence 0.65 Published 2005 Journal Pharmacol. Ther. Section Abstract Doc Link 15781124 Disease Relevance 0 Pain Relevance 0.23
Glucuronidation of 1'-HE was not detected in cells expressing UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, and UGT1A10. 1'-HE glucuronidation in 27 individual human liver samples significantly (p < 0.05) correlated with the glucuronidation of other UGT2B7 substrates (morphine and ibuprofen).
Gene_expression (expressing) of UGT1A7 in liver associated with morphine
4) Confidence 0.54 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12657745 Disease Relevance 0 Pain Relevance 0.09
Therefore, the combination in homozygosis at *28, UGT1A7-57G, UGT1A3-66C and UGT1A7 was identified as highly predictive of severe hyperbilirubinemia under ATV therapy.41

Toxicity

Gene_expression (identified) of UGT1A7 associated with toxicity and hyperbilirubinemia
5) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.76 Pain Relevance 0

General Comments

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