INT109478

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Context Info
Confidence 0.10
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nlrp5) mitochondrion (Nlrp5) nucleolus (Nlrp5)
nucleus (Nlrp5) protein complex (Nlrp5) cytoplasm (Nlrp5)
Nlrp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 98.92 Very High Very High Very High
antinociception 3 98.56 Very High Very High Very High
Eae 1 96.40 Very High Very High Very High
addiction 5 95.44 Very High Very High Very High
withdrawal 1 92.00 High High
Analgesic 1 82.76 Quite High
agonist 2 75.52 Quite High
opioid receptor 1 68.92 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Morphine Dependence 3 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study provides evidence that stimulation of the OP4 receptor suppresses acute morphine antinociception, but is not sufficient to inhibit the development of morphine dependence in mice.
Positive_regulation (stimulation) of OP4 associated with addiction, antinociception and morphine
1) Confidence 0.10 Published 2003 Journal Neuroreport Section Abstract Doc Link 12657894 Disease Relevance 0.26 Pain Relevance 1.44

General Comments

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