INT109481

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 2
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 99.62 Very High Very High Very High
chemokine 2 99.14 Very High Very High Very High
Analgesic 2 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 3 99.62 Very High Very High Very High
Apoptosis 2 99.12 Very High Very High Very High
Viremia 6 94.72 High High
Sprains And Strains 8 89.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 50 82.56 Quite High
Infection 16 37.52 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Fatigue 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIMS: To quantitatively determine the influence of estradiol on acinar cell apoptosis and chronic pancreatitis; assess its effects on infiltration of CD4 and CD8 T cells in the pancreas; investigate the role of testosterone on chronic pancreatitis in 20-week-old male WBN/Kob rats; and determine the impact of estradiol on proliferation of splenocytes derived from these animals in vitro.
Regulation (effects) of CD4 Binding (infiltration) of in T cells associated with apoptosis and chronic pancreatitis
1) Confidence 0.42 Published 2003 Journal Pancreas Section Abstract Doc Link 12657966 Disease Relevance 0.45 Pain Relevance 0.27
ENF-resistance has not been shown to confer cross-resistance to other inhibitors including fusion inhibitors, coreceptor inhibitors, and agents that target CD4 binding.
Regulation (target) of CD4 Binding (binding) of
2) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504070 Disease Relevance 0.16 Pain Relevance 0
They found that ENF-resistance did not confer cross-resistance to other inhibitors including fusion inhibitors, chemokine receptor blocking agents, and agents that target CD4 binding.
Regulation (target) of CD4 Binding (binding) of associated with chemokine
3) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504070 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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