INT109511

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 1
Speculated 10
Reported most in Body
Documents 133
Total Number 148
Disease Relevance 113.22
Pain Relevance 14.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neural 8
lung 7
brain 3
liver 3
neurons 3
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 8 100.00 Very High Very High Very High
qutenza 54 99.84 Very High Very High Very High
Eae 115 99.50 Very High Very High Very High
Morphine 240 99.40 Very High Very High Very High
Paracetamol 13 99.22 Very High Very High Very High
allodynia 2 99.00 Very High Very High Very High
Neuropathic pain 8 98.60 Very High Very High Very High
Thermal hyperalgesia 2 98.50 Very High Very High Very High
carrageenan induced 6 98.04 Very High Very High Very High
cytokine 262 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 4763 100.00 Very High Very High Very High
Death 1364 100.00 Very High Very High Very High
Cancer 1322 100.00 Very High Very High Very High
Injury 498 99.96 Very High Very High Very High
Ureteral Obstruction 84 99.42 Very High Very High Very High
Hemorrhagic Shock 561 99.40 Very High Very High Very High
Coronary Artery Disease 11 99.32 Very High Very High Very High
Disease Progression 29 99.20 Very High Very High Very High
Carcinoma 67 99.04 Very High Very High Very High
Neuropathic Pain 10 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to test the association between the level of BAX expression and the ability to activate the apoptotic program, HCT116BAX -/- cells were co-transfected with a pTRE-plasmid, carrying a tetracycline responsive promoter expressing either GFP-BAX or GFP, and pTetON, which codes for the reverse tetracycline transcription activator, rtTA.
Gene_expression (expression) of BAX associated with apoptosis
1) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.56 Pain Relevance 0
Susceptibility in BAX-deficient cells can be rescued if they express an exogenous BAX gene, but only after a critical level of expression has been achieved.
Gene_expression (express) of BAX gene
2) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.99 Pain Relevance 0.10
Treatment of mice with 100, 200, or 400 mg/kg/day of paeonol significantly inhibited the growth of the HepA tumor in mice, induced HepA cell apoptosis as demonstrated by light microscopy and electron microscopy analyses, decreased the expression of Bcl-2 and increased the expression of Bax in HepA tumor tissues in a dose-related manner.
Gene_expression (expression) of Bax associated with cancer and apoptosis
3) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.30 Pain Relevance 0.12
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Gene_expression (expression) of bax in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
4) Confidence 0.75 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.15 Pain Relevance 0.91
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Gene_expression (expression) of Bax in cecum associated with apoptosis
5) Confidence 0.69 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.97 Pain Relevance 0.05
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Gene_expression (expression) of Bax in cecum associated with apoptosis
6) Confidence 0.69 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.94 Pain Relevance 0.05
g/ml, pro-apoptotic protein Bax expression was up regulated in a time-dependent manner; the anti-apoptotic protein Bcl-2 was down regulated at 12 h and 24 h time points, but slightly up regulated at 48 h time point.
Gene_expression (expression) of Bax associated with apoptosis
7) Confidence 0.68 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.54 Pain Relevance 0
Cells expressing the GFP-BAX fusion protein, however, exhibited a substantial and significant increase in cell death, but only after treatment with indomethacin (P = 0.0001, compared to GFP-transfected cells, Figure 1B).
Gene_expression (expressing) of GFP-BAX associated with death
8) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.73 Pain Relevance 0.03
Even though not directly relevant to the balance between anti-apoptotic and BH3-only BCL2 family proteins, conditions that result in lower than normal BAX expression can also affect cell death.
Gene_expression (expression) of BAX associated with apoptosis and death
9) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.93 Pain Relevance 0.04
Cells transfected with pTRE-GFP-BAX exhibited only 17.6% of the level of fusion protein detected in doubly transfected cells in 0 ng/ml DOX.
Gene_expression (transfected) of pTRE-GFP-BAX
10) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.49 Pain Relevance 0
In order to test the association between the level of BAX expression and the ability to activate the apoptotic program, HCT116BAX -/- cells were co-transfected with a pTRE-plasmid, carrying a tetracycline responsive promoter expressing either GFP-BAX or GFP, and pTetON, which codes for the reverse tetracycline transcription activator, rtTA.
Gene_expression (expressing) of GFP-BAX associated with apoptosis
11) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.52 Pain Relevance 0
GFP-BAX expression stimulated by 0-0.5 ng/ml DOX was insufficient to cause cell death above this background level (P = 0.40) (Figure 3A).
Gene_expression (expression) of GFP-BAX associated with death
12) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.60 Pain Relevance 0
The cell death response in HCT116BAX-/- cells is rapidly saturated with increasing levels of exogenous GFP-Bax expression
Gene_expression (expression) of GFP-Bax associated with death
13) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.62 Pain Relevance 0
The primers used to quantify Bax cDNA were: 5'TTC ATC CAG GAT CGA GCA GG (forward) and 5' CAT CAG CAA ACA TGT CAG C (reverse).
Gene_expression (cDNA) of Bax
14) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.07 Pain Relevance 0
The activation of BAX during apoptosis is simplistically divided into four basic steps, including initial activation (conformational change) of cytosolic monomers, translocation to the MOM and insertion into this membrane, secondary recruitment of inactivate BAX monomers by MOM-bound BAX molecules, and aggregation of bound and recruited BAX molecules into oligomers that enable the release of cytochrome c.
Gene_expression (molecules) of BAX associated with apoptosis
15) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.55 Pain Relevance 0
Influence of Dox treatment on Bax expression
Gene_expression (expression) of Bax
16) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.16 Pain Relevance 0
Expression of Bax fusion proteins, activation of caspase-3, as well as cell genesis and neurogenesis were not modified by Dox treatment in the SVZ-OB system, the second main neurogenic area of the adult brain.
Gene_expression (Expression) of Bax in adult brain associated with neurodegenerative disease
17) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.80 Pain Relevance 0
Activation of transgenes with Dox treatment resulted in the overexpression of Bax proteins in nestin expressing cells in the subgranular zone of the DG where neural precursors reside.
Gene_expression (overexpression) of Bax in neural
18) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.62 Pain Relevance 0
Doxycycline treatment induced the expression of Bax clusters in an inducible and reversible way.
Gene_expression (ed the exp) of Bax
19) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.07 Pain Relevance 0
Furthermore, in other brain areas, such as the cerebellum, the cortex or the striatum neither the expression of Bax fusion proteins nor the number of cells expressing the activated form of caspase-3 were modified.
Gene_expression (expression) of Bax in brain
20) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.85 Pain Relevance 0

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