INT109512

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.04
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neuroblasts 2
liver 2
cecum 2
epithelial cells 2
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 99.88 Very High Very High Very High
allodynia 1 99.38 Very High Very High Very High
Thermal hyperalgesia 1 98.88 Very High Very High Very High
Spinal cord 5 89.36 High High
Sciatic nerve 3 87.76 High High
Dorsal horn 2 84.96 Quite High
cytokine 54 83.64 Quite High
Neuropathic pain 4 79.56 Quite High
metalloproteinase 41 69.04 Quite High
Inflammation 130 66.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 367 100.00 Very High Very High Very High
Injury 31 99.88 Very High Very High Very High
Neuropathic Pain 5 99.38 Very High Very High Very High
Huntington's Chorea 1 99.00 Very High Very High Very High
Hyperalgesia 1 98.88 Very High Very High Very High
Carcinoma 4 95.72 Very High Very High Very High
Cancer 172 91.60 High High
Obesity 132 89.44 High High
Targeted Disruption 34 89.20 High High
Aging 106 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Negative_regulation (decreased) of Gene_expression (levels) of bax associated with allodynia, eae and thermal hyperalgesia
1) Confidence 0.42 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.42 Pain Relevance 1.14
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Negative_regulation (decreased) of Gene_expression (expression) of Bax in cecum associated with apoptosis
2) Confidence 0.38 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.94 Pain Relevance 0.05
It also decreased AAP-induced liver injury, accompanied by decreased expression of pJNK, Bax and tBid in the liver.
Negative_regulation (decreased) of Gene_expression (expression) of Bax in liver
3) Confidence 0.33 Published 2010 Journal J. Sci. Food Agric. Section Body Doc Link 20355050 Disease Relevance 0.09 Pain Relevance 0
In contrast, GW0742 treatment prevented the zymosan-induced Bax expression (Figure 16A, see densitometric analysis Figure 16A1).
Negative_regulation (prevented) of Gene_expression (expression) of Bax
4) Confidence 0.29 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.46 Pain Relevance 0
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Negative_regulation (targeted) of Gene_expression (mutation) of BAX associated with apoptosis
5) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
On the contrary, T0901317 (20 mg/kg) treatment prevented the carrageenan-induced Bax expression (Fig. 7Ae, see densitometry analysis 7Ae1).
Negative_regulation (prevented) of Gene_expression (expression) of Bax
6) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.53 Pain Relevance 0.03
A decrease in p53 dependent transcription, and in levels of Bax, which is regulated by p53 [30], was observed in COS cells expressing Hr.
Negative_regulation (decrease) of Gene_expression (levels) of Bax
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.16 Pain Relevance 0
Strikingly, we observed a reduction of Bax expression in epithelial cells in some areas of tacrolimus treated mucosa and this reduction was also present in the carcinoma cells (Figure 1I to 1K).
Negative_regulation (reduction) of Gene_expression (expression) of Bax in epithelial cells associated with carcinoma
8) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.48 Pain Relevance 0
We had previously observed that estrogen prevented apoptosis following p53 activation and decreased the expression of the mitochondrial-associated pro-apoptotic protein Bax in differentiating cerebral cortical neuroblasts [37].
Negative_regulation (decreased) of Gene_expression (expression) of Bax in neuroblasts associated with apoptosis
9) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.20 Pain Relevance 0
While our data indicates that estrogen suppresses the expression of p53-induced proteins like Bax [37] and Fas, other data indicates that p53 can suppress estrogen receptor activation [85], by preventing ER-alpha binding to EREs.
Negative_regulation (suppresses) of Gene_expression (expression) of Bax
10) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.13 Pain Relevance 0
While the expression of the anti-apoptotic molecule Mcl-1 is decreased, that of the pro-apoptotic molecule Bax is increased.
Negative_regulation (decreased) of Gene_expression (expression) of Bax associated with apoptosis
11) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.11 Pain Relevance 0.10
Furthermore, quantitative realtime PCR analysis suggested that the protective effect of insulin is mediated through stimulation of Bcl-2 mRNA rather than suppression of Bax mRNA expression (Figure S2C, S2D).
Negative_regulation (suppression) of Gene_expression (expression) of Bax mRNA
12) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.78 Pain Relevance 0.12

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