INT109513

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 29.52
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neural 4
MDA-MB-231 4
BxPC-3 3
liver 2
cecum 2
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 48 99.48 Very High Very High Very High
Neuropathic pain 4 99.00 Very High Very High Very High
cva 50 97.16 Very High Very High Very High
Dorsal horn 2 97.12 Very High Very High Very High
Spinal cord 7 96.64 Very High Very High Very High
Eae 37 95.64 Very High Very High Very High
Sciatic nerve 3 94.40 High High
aspirin 14 93.00 High High
cytokine 40 90.72 High High
Hippocampus 123 89.04 High High
Disease Link Frequency Relevance Heat
Apoptosis 1140 100.00 Very High Very High Very High
Death 342 99.92 Very High Very High Very High
Cancer 383 99.64 Very High Very High Very High
Neuropathic Pain 5 99.00 Very High Very High Very High
Targeted Disruption 85 98.70 Very High Very High Very High
Pancreatic Cancer 37 98.70 Very High Very High Very High
Hepatotoxicity 39 98.02 Very High Very High Very High
Bullous Skin Disease 304 97.44 Very High Very High Very High
Neurodegenerative Disease 277 97.20 Very High Very High Very High
Hemorrhage 50 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.
Positive_regulation (increased) of Gene_expression (expression) of bax in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord
1) Confidence 0.67 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.15 Pain Relevance 0.91
Doxycycline treatment induced the expression of Bax clusters in an inducible and reversible way.
Positive_regulation (atment ) of Gene_expression (ed the exp) of Bax
2) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.07 Pain Relevance 0
Activation of transgenes with Dox treatment resulted in the overexpression of Bax proteins in nestin expressing cells in the subgranular zone of the DG where neural precursors reside.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bax in neural
3) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.62 Pain Relevance 0
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with qutenza, cancer and apoptosis
4) Confidence 0.56 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.78 Pain Relevance 0.87
More specifically, we generated transgenic mice in which the death of neural precursors can be selectively induced by over-expressing the pro-apoptotic protein Bax.
Positive_regulation (induced) of Gene_expression (expressing) of Bax in neural associated with targeted disruption, apoptosis and death
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.86 Pain Relevance 0.04
In contrast, GW0742 treatment prevented the zymosan-induced Bax expression (Figure 16A, see densitometric analysis Figure 16A1).
Positive_regulation (induced) of Gene_expression (expression) of Bax
6) Confidence 0.47 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.45 Pain Relevance 0
The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein

Background

Positive_regulation (increasing) of Gene_expression (expression) of GFP-BAX associated with cancer and apoptosis
7) Confidence 0.47 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2964639 Disease Relevance 0.96 Pain Relevance 0
This is partially in line with recent observations showing pulmonary upregulation of Bax protein expression in rats following lactated Ringer solution and hetastarch resuscitated HS [44].
Positive_regulation (upregulation) of Gene_expression (expression) of Bax associated with hemorrhagic shock
8) Confidence 0.46 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.38 Pain Relevance 0.03
On the contrary, T0901317 (20 mg/kg) treatment prevented the carrageenan-induced Bax expression (Fig. 7Ae, see densitometry analysis 7Ae1).
Positive_regulation (induced) of Gene_expression (expression) of Bax
9) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.52 Pain Relevance 0.03
Treatment of mice with 100, 200, or 400 mg/kg/day of paeonol significantly inhibited the growth of the HepA tumor in mice, induced HepA cell apoptosis as demonstrated by light microscopy and electron microscopy analyses, decreased the expression of Bcl-2 and increased the expression of Bax in HepA tumor tissues in a dose-related manner.
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with cancer and apoptosis
10) Confidence 0.45 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.30 Pain Relevance 0.12
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Positive_regulation (increased) of Gene_expression (expression) of Bax in cecum associated with apoptosis
11) Confidence 0.45 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.94 Pain Relevance 0.05
Upregulation of Bax/Bcl-2 ratio
Positive_regulation (Upregulation) of Gene_expression (ratio) of Bax
12) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.35 Pain Relevance 0
The cell death response in HCT116BAX-/- cells is rapidly saturated with increasing levels of exogenous GFP-Bax expression
Positive_regulation (increasing) of Gene_expression (expression) of GFP-Bax associated with death
13) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.63 Pain Relevance 0
Cells transfected with pTetON alone, or pTRE-GFP-BAX alone, acted as negative controls for transgene expression.
Positive_regulation (transfected) of Gene_expression (transfected) of pTRE-GFP-BAX
14) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.46 Pain Relevance 0
Cells transfected with pTRE-GFP-BAX exhibited only 17.6% of the level of fusion protein detected in doubly transfected cells in 0 ng/ml DOX.
Positive_regulation (transfected) of Gene_expression (transfected) of pTRE-GFP-BAX
15) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.49 Pain Relevance 0
In conclusion, these observations confirm that in bigenic mice Dox treatment induces the over-expression of Bax transgenes in the DG leading to a specific inhibition of hippocampal neurogenesis.


Positive_regulation (induces) of Gene_expression (expression) of Bax associated with neurodegenerative disease
16) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.56 Pain Relevance 0.08
GFP-BAX expression stimulated by 0-0.5 ng/ml DOX was insufficient to cause cell death above this background level (P = 0.40) (Figure 3A).
Positive_regulation (stimulated) of Gene_expression (expression) of GFP-BAX associated with death
17) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.60 Pain Relevance 0
To titrate the expression of the fusion protein, GFP-BAX was cloned into a tetracycline sensitive expression cassette and cotransfected with a plasmid expressing the rtTA transcription factor into HCT116BAX-/- cells.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of GFP-BAX
18) Confidence 0.41 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2964639 Disease Relevance 0.93 Pain Relevance 0
Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.
Positive_regulation (increased) of Gene_expression (expression) of Bax in BxPC-3 associated with qutenza
19) Confidence 0.41 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.94 Pain Relevance 0.70
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Positive_regulation (increased) of Gene_expression (expression) of Bax associated with qutenza, cancer and apoptosis
20) Confidence 0.41 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.78 Pain Relevance 0.87

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