INT109530

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.01
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
epithelial cell 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 98.60 Very High Very High Very High
cINOD 19 85.24 High High
Inflammation 27 75.00 Quite High
COX2 1 25.00 Low Low
cytokine 11 8.16 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 164 97.60 Very High Very High Very High
Malignant Neoplastic Disease 5 96.00 Very High Very High Very High
Parkinson's Disease 1 94.52 High High
Stomach Cancer 6 90.48 High High
Cancer 128 79.96 Quite High
Reprotox - General 1 3 78.16 Quite High
INFLAMMATION 29 75.00 Quite High
Death 28 75.00 Quite High
Toxicity 3 71.32 Quite High
Stress 5 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that IR-induced bax and p21(WAF1/Cip1) protein expression were attenuated selectively in normal stromal and epithelial cell cultures, yet maintained their p53-dependency in malignant cell lines.
Negative_regulation (attenuated) of Positive_regulation (induced) of bax in epithelial cell associated with malignant neoplastic disease
1) Confidence 0.42 Published 2003 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 12664070 Disease Relevance 0.91 Pain Relevance 0.10
The siRNA for PUMA inhibited the celecoxib-induced activation and translocation of Bax, release of cytochrome c into the cytosol and induction of apoptosis, suggesting that PUMA plays an important role in celecoxib-induced mitochondrial dysfunction and the resulting apoptosis.
Negative_regulation (inhibited) of Positive_regulation (activation) of Bax associated with parkinson's disease and apoptosis
2) Confidence 0.38 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17368424 Disease Relevance 1.02 Pain Relevance 0.20
Bcl-2 is the best described member of this family preventing Bax activation [51].
Negative_regulation (preventing) of Positive_regulation (activation) of Bax
3) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.07 Pain Relevance 0

General Comments

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