INT109535

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 116
Total Number 116
Disease Relevance 84.61
Pain Relevance 14.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
fibroblasts 6
vasculature 6
macrophages 3
granulation 3
Epithelium 3
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 902 100.00 Very High Very High Very High
cytokine 272 100.00 Very High Very High Very High
Arthritis 612 99.84 Very High Very High Very High
cINOD 112 99.64 Very High Very High Very High
metalloproteinase 213 99.48 Very High Very High Very High
Calcitonin gene-related peptide 17 99.28 Very High Very High Very High
chemokine 71 99.26 Very High Very High Very High
imagery 265 99.10 Very High Very High Very High
ischemia 76 99.04 Very High Very High Very High
positron emission tomography 37 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2313 100.00 Very High Very High Very High
INFLAMMATION 975 100.00 Very High Very High Very High
Hypoxia 185 100.00 Very High Very High Very High
Infection 158 100.00 Very High Very High Very High
Adhesions 61 100.00 Very High Very High Very High
Corneal Neovascularization 213 99.98 Very High Very High Very High
Injury 1107 99.84 Very High Very High Very High
Rheumatoid Arthritis 633 99.84 Very High Very High Very High
Ovarian Cancer 143 99.84 Very High Very High Very High
Reprotox - General 1 39 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic animals expressing human VEGF165 under a neuron-specific promoter, as well as intracerebroventricular administration of VEGF both are shown to increase Akt activity and enhance neuronal survival after focal cerebral ischemia [23,44].
Gene_expression (expressing) of VEGF in neuronal associated with brain hemorrhage, targeted disruption, ischemia and intracerebroventricular
1) Confidence 0.75 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.28 Pain Relevance 0.14
For example, vessels within tumors expressing predominantly the VEGF189 isoform, which has a strong heparin-binding affinity and thus is highly localized, are much less leaky than the vessels in tumors expressing the more diffusible VEGF165 and VEGF121 isoforms [45].
Gene_expression (expressing) of VEGF in vessels associated with cancer
2) Confidence 0.75 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64829 Disease Relevance 0.49 Pain Relevance 0.03
The transplanted cells were in proximity of the newly formed vasculature and expressed several proangiogenic factors, such as VEGF-A, G-CSF, GM-CSF, and MMP3.
Gene_expression (expressed) of VEGF in vasculature
3) Confidence 0.75 Published 2008 Journal Stem Cells Section Abstract Doc Link 18583536 Disease Relevance 0.27 Pain Relevance 0.14
TZDs can reduce the production of proangiogenic FGF and VEGF
Gene_expression (production) of VEGF
4) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396401 Disease Relevance 0.75 Pain Relevance 0.05
Another series of clinical experimentation was based on the delivery of a defective Ad expressing the VEGF121 cDNA under the control of the CMV enhancer/promoter (Ad(GV)VEGF121.10).
Gene_expression (expressing) of VEGF associated with cytomegalovirus infection
5) Confidence 0.75 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.29 Pain Relevance 0.05
Angiotensin II is a known stimulus for the expression of vascular endothelial growth factor (VEGF), which is associated with the induction of retinal neovascularization (Aiello et al 1995; Gilbert et al 1998; Otani et al 2000; Okada et al 2001).
Gene_expression (expression) of vascular endothelial growth factor associated with retinal neovascularization
6) Confidence 0.75 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.96 Pain Relevance 0.03
Some RA synovial fibroblasts spontaneously produced VEGF-A, however VEGF-A production was significantly increased by rIL-17 even at low concentrations (1 ng/ml). rIL-17 at higher concentrations also significantly induced IL-6 secretion by RA synovial fibroblasts, a cytokine involved in both inflammation and angiogenesis (reviewed in [27]).
Gene_expression (produced) of VEGF in fibroblasts associated with inflammation, cytokine and arthritis
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.53 Pain Relevance 0.29
These animals also showed cerebrovascular remodeling characterized by increased vessel tortuosity, vascular endothelial growth factor (VEGF) expression, and matrix metalloproteinase (MMP)-2 and -9 activity (4).
Gene_expression (expression) of VEGF associated with metalloproteinase
8) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 1.60 Pain Relevance 0.13
As the RPE produces VEGF, such aberrant vessels usually proliferate and appear in some cases to form connections with the choroidal vascular system.
Gene_expression (produces) of VEGF in RPE
9) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.24 Pain Relevance 0.03
Both VEGFRs are expressed almost exclusively on the surface of EC.
Gene_expression (expressed) of VEGF
10) Confidence 0.75 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.55 Pain Relevance 0
These animals also showed cerebrovascular remodeling characterized by increased vessel tortuosity, vascular endothelial growth factor (VEGF) expression, and matrix metalloproteinase (MMP)-2 and -9 activity (4).
Gene_expression (expression) of vascular endothelial growth factor associated with metalloproteinase
11) Confidence 0.75 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 1.73 Pain Relevance 0.16
No vascular endothelial growth factor, interleukin-6 or tumor necrosis factor-alpha was detected in urine before or after stimulation.
Gene_expression (detected) of vascular endothelial growth factor in urine
12) Confidence 0.73 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0 Pain Relevance 0
Analysis of VEGFA mRNA expression by RT-PCR
Gene_expression (expression) of VEGFA mRNA
13) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.14 Pain Relevance 0
Vascular endothelial growth factor A(VEGFA), a mitogen for vascular endothelium, is expressed not only by skin resident cells but also by inflammatory cells when healing process happens.
Gene_expression (expressed) of Vascular endothelial growth factor in skin associated with inflammation
14) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.51 Pain Relevance 0.14
On day 3, the MVD, area and IOD of VEGFA expression were at the climax among all three groups along the whole healing process (Fig. 2).
Gene_expression (expression) of VEGFA in climax
15) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.49 Pain Relevance 0.03
Monounsaturated fatty acid (MUFA) such as oleic acid and polyunsaturated fatty acid (PUFA) such as arachidonic acid affect the function of vessels in several aspects, involved in newly-formed micro-vessels formation and VEGFA expression in the wound healing process [21,22].
Gene_expression (expression) of VEGFA in vessels associated with wound healing
16) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.75 Pain Relevance 0.08
Vascular endothelial growth factor A(VEGFA), a mitogen for vascular endothelium, is expressed not only by skin resident cells but also by inflammatory cells when healing process happens.
Gene_expression (expressed) of VEGFA in skin associated with inflammation
17) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.45 Pain Relevance 0.14
It is reported that low concentration of oxygen free radicals in the wound site can promote angiogenesis by inducing VEGFA expression in keratinocytes [30] and macrophages [31] as well as stimulate collagen production [32].
Gene_expression (expression) of VEGFA in keratinocytes associated with injury
18) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.71 Pain Relevance 0.04
On day 3, the VEGFA mRNA expression in wounds determined by RT-PCR was seen in all three groups (Fig. 3a).
Gene_expression (expression) of VEGFA mRNA associated with injury
19) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.35 Pain Relevance 0
VEGFA mRNA expression by RT-PCR and VEGFA protein expression by Western-blot
Gene_expression (expression) of VEGFA protein
20) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.35 Pain Relevance 0

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