INT109536

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.35
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
chondrocytes 2
monocyte 1
vessels 1
platelet 1
nodules 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 99.04 Very High Very High Very High
cINOD 19 96.72 Very High Very High Very High
palliative 46 94.94 High High
ischemia 32 84.84 Quite High
Osteoarthritis 4 80.80 Quite High
Pain 5 79.28 Quite High
anesthesia 2 78.88 Quite High
cva 42 78.00 Quite High
Taxol 14 50.80 Quite High
corticosteroid 2 29.12 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 60 99.84 Very High Very High Very High
Polyps 5 99.84 Very High Very High Very High
Cancer 403 99.78 Very High Very High Very High
Age-related Macular Degeneration 3 99.22 Very High Very High Very High
Cv Unclassified Under Development 63 98.80 Very High Very High Very High
Disorder Of Lipid Metabolism 5 98.00 Very High Very High Very High
INFLAMMATION 40 96.52 Very High Very High Very High
Reprotox - General 1 3 95.08 Very High Very High Very High
Carcinoma 30 94.36 High High
Hyperglycemia 10 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor.
Negative_regulation (inhibiting) of vascular endothelial growth factor associated with cancer
1) Confidence 0.46 Published 2003 Journal Acta Oncol Section Title Doc Link 12665333 Disease Relevance 0.70 Pain Relevance 0.29
inhibiting VEGF itself using neutralizing anti-VEGF monoclonal antibodies or soluble receptorsVEGF receptor (VEGFR) blockade using anti-VEGFR monoclonal antibodiesinhibiting VEGFR signalling with small molecule VEGFR tyrosine kinase inhibitors.


Negative_regulation (blockade) of VEGF
2) Confidence 0.41 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012552 Disease Relevance 0.84 Pain Relevance 0
100 were treated with a single intraperitoneal injection of VEGF165 recombinant human protein (2 ?
Negative_regulation (injection) of VEGF
3) Confidence 0.41 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64829 Disease Relevance 0.57 Pain Relevance 0.03
The high alendronate dose (100 µM) similarly reduced VEGF 120 and VEGF 164 isoform levels by 32-36% but also reduced the VEGF 188 isoform level to the same extent (Fig. 1; p < 0.01).
Negative_regulation (reduced) of VEGF 188 isoform
4) Confidence 0.36 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
VEGF Isoforms

Growth plate chondrocytes treated with the low dose of alendronate (10µM) exhibited a 37% decrease in VEGF 120 and VEGF 164 isoform levels whereas the VEGF 188 isoform level was unchanged (Fig. 1; p < 0.01).

Negative_regulation (decrease) of VEGF 164 in chondrocytes
5) Confidence 0.36 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
VEGF Isoforms

Growth plate chondrocytes treated with the low dose of alendronate (10µM) exhibited a 37% decrease in VEGF 120 and VEGF 164 isoform levels whereas the VEGF 188 isoform level was unchanged (Fig. 1; p < 0.01).

Negative_regulation (decrease) of VEGF 120 in chondrocytes
6) Confidence 0.36 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
Another group of mice received vascular endothelial growth factor (VEGF) 121, the most soluble of VEGF isoforms, subcutaneously through a mini osmotic pump (Alzet, Cupertino, CA) (20 µg/kg/day) from day 4 to day 10 of pregnancy.
Negative_regulation (received) of vascular endothelial growth factor
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.26 Pain Relevance 0.08
In the palliative resection group, the number of lung metastatic nodules increased markedly as compared to the sham operation group (14.3 ± 4.7 versus 8.7 ± 3.6, P < 0.05); tumor matrix metalloproteinase 2 (MMP2) activity was elevated by 1.4-fold, with up-regulation of vascular endothelial growth factor (VEGF) and down-regulation of tissue inhibitor of metalloproteinase 2 (TIMP2).
Negative_regulation (regulation) of vascular endothelial growth factor in nodules associated with cancer, metalloproteinase and palliative
8) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2976755 Disease Relevance 0.89 Pain Relevance 0.71
Furthermore, it has been demonstrated that lenalidomide inhibits the vascular endothelial growth factor–induced association between cadherin 5, CD31, and ?
Negative_regulation (inhibits) of vascular endothelial growth factor
9) Confidence 0.19 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 1.07 Pain Relevance 0.07
The mechanism of antiangiogenic therapy–related hypertension is not fully understood but it is thought to be related to vascular endothelial growth factor inhibition, which, through decreased NO-synthase activity, leads to decreases in NO production in the walls of arterioles and other resistance vessels.
Negative_regulation (inhibition) of vascular endothelial growth factor in vessels associated with cv unclassified under development
10) Confidence 0.19 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 1.20 Pain Relevance 0.03
Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (PDGF) or vascular endothelial growth factor (VEGF) signaling lowers the IFP of tumors and improve chemotherapy.
Negative_regulation (inhibitors) of vascular endothelial growth factor in platelet associated with cancer
11) Confidence 0.19 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781164 Disease Relevance 0.70 Pain Relevance 0.03
The monocyte migration toward vascular endothelial growth factor-A and monocyte chemotactic protein-1 was strongly reduced in diabetic rabbits.
Negative_regulation (reduced) of vascular endothelial growth factor-A in monocyte associated with diabetes mellitus
12) Confidence 0.18 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551694 Disease Relevance 1.04 Pain Relevance 0.04
The proangiogenic protein vascular derived endothelial growth factor was decreased in polyps treated with rofecoxib, whereas membrane-associated beta-catenin increased in rofecoxib-treated polyps.
Negative_regulation (decreased) of endothelial growth factor associated with polyps
13) Confidence 0.14 Published 2003 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 12902858 Disease Relevance 0.90 Pain Relevance 0.12
Current therapies available for the treatment of the “wet” form of AMD involve the use of small molecules to block the activity of vascular endothelial growth factor, but entail recurring injections to maintain this inhibitory effect [59]–[61].
Negative_regulation (block) of vascular endothelial growth factor associated with age-related macular degeneration
14) Confidence 0.11 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.82 Pain Relevance 0
vascular endothelial growth factor (VEGF) levels were decreased [62].
Negative_regulation (decreased) of vascular endothelial growth factor
15) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422868 Disease Relevance 1.36 Pain Relevance 0

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