INT109559

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 1.30
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
vesicle 4
articular 1
nerve 1
neurons 1
Astrocytes 1
Napa (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 130 100.00 Very High Very High Very High
Glutamate 32 99.98 Very High Very High Very High
Neuropeptide 1 99.56 Very High Very High Very High
Nerve growth factor 13 99.28 Very High Very High Very High
substance P 4 98.56 Very High Very High Very High
Calcitonin gene-related peptide 1 97.44 Very High Very High Very High
Glutamate receptor 9 95.16 Very High Very High Very High
Pain 109 94.64 High High
Dopamine 47 94.60 High High
Action potential 51 90.60 High High
Disease Link Frequency Relevance Heat
Frailty 2 96.92 Very High Very High Very High
Arthralgia 11 95.04 Very High Very High Very High
Paralysis 55 92.00 High High
Ganglion Cysts 52 86.40 High High
Epilepsy 29 83.24 Quite High
Pain 104 75.00 Quite High
Cervical Cancer 1 64.48 Quite High
Headache 11 62.96 Quite High
Tension-type Headache 1 62.24 Quite High
Myofascial Pain Syndromes 1 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next examined whether the tomosyn deficiency affected the cellular localization of SNARE proteins.
Localization (localization) of SNARE
1) Confidence 0.61 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.05
The decreased immunostaining intensity for SNAP-25 is explained by the decreased formation of the oligomerized SNARE complex and the diffuse localization of SNAP-25 on the synaptic membrane in tomosyn-deficient mice.


Localization (localization) of SNARE
2) Confidence 0.61 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.03
But, in contrast to the consensus and clarity about SNARE proteins, recent data on SM proteins in different systems produce an uncomfortable heterogeneity of ideas about their exact role, their site of action and their relation to SNARE proteins.
Localization (relation) of SNARE
3) Confidence 0.57 Published 2003 Journal Trends Cell Biol. Section Abstract Doc Link 12667755 Disease Relevance 0.07 Pain Relevance 0.07
Tomosyn inhibits SNARE complex formation and neurotransmitter release by sequestering syntaxin-1 through its C-terminal vesicle-associated membrane protein (VAMP)–like domain (VLD).
Localization (release) of SNARE in vesicle associated with neurotransmitter
4) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.17
These results provide further evidence suggesting that tomosyn-enhanced oligomerization of the SNARE complex inhibits neurotransmitter release.
Localization (release) of SNARE associated with neurotransmitter
5) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.09 Pain Relevance 0.16
The sustained reduction of EPSPs in Frg. 1– and Frg. 2–injected neurons suggests that tomosyn-enhanced oligomerization of the SNARE complex potently inhibits neurotransmitter release.


Localization (release) of SNARE in neurons associated with neurotransmitter
6) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.09 Pain Relevance 0.21
In this study, we demonstrated that tomosyn regulates the oligomerization of the SNARE complex and inhibits SNARE-dependent neurotransmitter release.
Localization (release) of SNARE associated with neurotransmitter
7) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.08 Pain Relevance 0.21
In contrast, the use of SNAP25 N-terminal-derived peptides to modulate SNAP receptors (SNARE) complex assembly and neurosecretion has not been explored.
Localization (neurosecretion) of SNARE
8) Confidence 0.36 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0 Pain Relevance 0
After NGF-differentiated PC12 cells had been treated for 5 min with SNAP (10, 30, 100 ?
Localization (treated) of SNAP associated with nerve growth factor
9) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.22
BoNTs have also been found to affect the release of multiple SNARE-dependent neuropeptides, including substance P, glutamate, and calcitonin gene-related peptide, all important mediators of articular pain transmission.15,22
Localization (release) of SNARE in articular associated with pain, arthralgia, glutamate, neuropeptide, calcitonin gene-related peptide and substance p
10) Confidence 0.18 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004655 Disease Relevance 0.51 Pain Relevance 0.77
The synapse offers an ideal site to test this hypothesis because both forms of secretion co-exist and the SNARE proteins involved in the process are well studied.
Localization (secretion) of SNARE in synapse
11) Confidence 0.08 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.05 Pain Relevance 0
As vesicles undergo fusion, the SNARE complex rearranges from a trans to a cis configuration such that all the SNARE proteins are localized to one membrane.
Localization (localized) of SNARE in vesicles
12) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0
Because SNARE complexes also mediate vesicle fusion along the constitutive secretory pathway [1,20], it is conceivable that this mechanism lies within the different structural and/or biochemical properties of SNARE complexes used for constitutive secretion and Ca2+-regulated exocytosis.
Localization (secretion) of SNARE in vesicle
13) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0
By enhancing the hydrophobic core of the molecule in the vicinity of layer +7, towards the C-terminal transmembrane helix, the mutant SNARE complex favors “constitutive-like” vesicle secretion either by increasing intermolecular interactions among the SNARE bundles or by stimulating vesicle docking and/or priming.
Localization (secretion) of SNARE in vesicle
14) Confidence 0.06 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.06 Pain Relevance 0
Astrocytes effect glutamate release upon a Ca2+ and SNARE-dependent mechanism [60, 61].
Localization (release) of SNARE in Astrocytes associated with glutamate
15) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.16 Pain Relevance 0.50
Eventually, the SNARE protein complex is regenerated, acetylcholine release resumes from the original nerve terminal, and axon sprouts retract (de Paiva 1999).
Localization (release) of SNARE in nerve
16) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656321 Disease Relevance 0.19 Pain Relevance 0.03

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