INT109578

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.09
Pain Relevance 10.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 4
muscle 2
masseter 2
polymodal neuron 1
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 122 100.00 Very High Very High Very High
nociceptor 78 100.00 Very High Very High Very High
Hyperalgesia 23 99.52 Very High Very High Very High
spinal dorsal horn 6 99.48 Very High Very High Very High
qutenza 131 99.36 Very High Very High Very High
Inflammation 27 98.66 Very High Very High Very High
Pain 88 98.64 Very High Very High Very High
Root ganglion neuron 10 98.56 Very High Very High Very High
central sensitization 3 98.32 Very High Very High Very High
ischemia 11 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 26 99.52 Very High Very High Very High
Acidosis 144 99.50 Very High Very High Very High
INFLAMMATION 19 98.66 Very High Very High Very High
Pain 57 98.64 Very High Very High Very High
Ganglion Cysts 154 98.36 Very High Very High Very High
Nociception 107 98.34 Very High Very High Very High
Cv Unclassified Under Development 26 97.56 Very High Very High Very High
Hypersensitivity 7 97.48 Very High Very High Very High
Ischemic Heart Disease 3 97.20 Very High Very High Very High
Cv General 3 Under Development 8 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, amiloride, which blocks ASICs when they are activated at lower pH, increases ASIC3 current evoked at pH 7.0.
Positive_regulation (increases) of ASIC3 associated with asic
1) Confidence 0.70 Published 2006 Journal Circ. Res. Section Abstract Doc Link 16873722 Disease Relevance 0.40 Pain Relevance 0.54
Upregulations of P2X(3) and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats.
Positive_regulation (Upregulations) of ASIC3 associated with hyperalgesia and nociceptor
2) Confidence 0.67 Published 2010 Journal Pain Section Title Doc Link 20378247 Disease Relevance 0.69 Pain Relevance 0.86
Furthermore, cisplatin treatment also induced muscle hyperalgesia in muscle afferent neurons in connection with the upregulation of P2X(3) and ASIC3.
Positive_regulation (upregulation) of ASIC3 in muscle associated with hyperalgesia
3) Confidence 0.67 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.79 Pain Relevance 0.84
Upregulation of TRPV2, P2X(3), and ASIC3 may play important roles in the mechanical hyperalgesia induced by cisplatin.
Positive_regulation (Upregulation) of ASIC3 associated with hyperalgesia
4) Confidence 0.67 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.87 Pain Relevance 0.98
ASIC3-mediated sustained depolarisation, and its regulation by neuropeptides, could thus be important in regulating polymodal neuron excitability particularly under inflammatory conditions where the expression levels of both NPFF precursor and ASIC3 are increased.
Positive_regulation (increased) of ASIC3 in polymodal neuron associated with inflammation and neuropeptide
5) Confidence 0.67 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.15 Pain Relevance 0.29
AA potentiates ASIC activation by a direct mechanism, because inhibition of AA metabolism had no effect on potentiation, and potentiation of single ASIC2a channels could be observed in cell-free patches.
Positive_regulation (activation) of ASIC associated with asic
6) Confidence 0.59 Published 2007 Journal Neuroscience Section Abstract Doc Link 17258862 Disease Relevance 0.37 Pain Relevance 0.44
Moreover, both extracellular lactate and extracellular ATP increase the sensitivity of ASIC3 to protons.
Positive_regulation (increase) of ASIC3
7) Confidence 0.50 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 16258623 Disease Relevance 0.79 Pain Relevance 0.45
One found ASIC3 and ASIC2 to co-localize in dorsal root ganglion neurons and to be present more often in larger neurons than in smaller [21].
Positive_regulation (found) of ASIC3 in neurons associated with ganglion cysts and root ganglion neuron
8) Confidence 0.45 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 1.24 Pain Relevance 0.89
In fact, practically all of the retrogradely labelled NF68-positive neurons also exhibited ASIC3-immunoreactivity.
Positive_regulation (exhibited) of ASIC3-immunoreactivity in neurons
9) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.23 Pain Relevance 0.32
A stimulus of pH 6.8, chosen to selectively stimulate ASIC3, elicited large current (>0.3 nA) in 56% (18/32) of small muscle afferents, but in only 11% (4/37) of small skin afferents (Fig. 5B).
Positive_regulation (stimulate) of ASIC3 in muscle
10) Confidence 0.41 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.30 Pain Relevance 0.36
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Positive_regulation (increased) of ASIC3 in neurons associated with inflammation
11) Confidence 0.40 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.42 Pain Relevance 0.43
For example, ASIC3 channels are activated by the modest changes in extracellular calcium and pH that accompany cardiac ischaemia and are highly expressed in a subset of cardiac sensory afferents that are presumed to transmit the pain of angina [5].
Positive_regulation (activated) of ASIC3 associated with ischemic heart disease, pain and angina
12) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.54 Pain Relevance 0.76
Almost all the masseter afferents isolated from the TG expressed significant amounts of at least one of the putative "nociceptive" ion channels we examined in this study; capsaicin activated TRPV1 channels, acid activated ASIC-3-like channels or ATP activated P2X3-like channels.
Positive_regulation (activated) of ASIC-3-like in masseter associated with nociception, qutenza, trigeminal ganglion and asic
13) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.73 Pain Relevance 0.75
Almost all the masseter afferents isolated from the TG expressed significant amounts of at least one of the putative "nociceptive" ion channels we examined in this study; capsaicin activated TRPV1 channels, acid activated ASIC-3-like channels or ATP activated P2X3-like channels.
Positive_regulation (activated) of ASIC-3-like in masseter associated with nociception, qutenza, trigeminal ganglion and asic
14) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.68 Pain Relevance 0.72
Recent evidence also indicates that under moderate acidosis (pH 7.0), amiloride may activate ASIC3 leading to sustained inward currents [108].
Positive_regulation (activate) of ASIC3 associated with acidosis
15) Confidence 0.27 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.16 Pain Relevance 0.18
Together, our results reveal that increased ASIC activity in SDH neurons promotes pain by central sensitization.
Positive_regulation (increased) of ASIC in neurons associated with pain, central sensitization, spinal dorsal horn and asic
16) Confidence 0.18 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.73 Pain Relevance 1.22

General Comments

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