INT109580

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc3r) signal transducer activity (Mc3r)
Mc3r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 4 96.36 Very High Very High Very High
corticosteroid 2 84.44 Quite High
Neuropathic pain 2 84.32 Quite High
antagonist 1 71.20 Quite High
Arthritis 1 62.92 Quite High
Inflammation 1 59.28 Quite High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 11 96.92 Very High Very High Very High
Neuropathic Pain 2 84.32 Quite High
Body Weight 1 78.36 Quite High
Hyperuricemia 1 61.28 Quite High
INFLAMMATION 1 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, a library of 18 peptides, in which a melanocortin-based sequence was systematically point-mutated, was screened for binding to and activity on the MC3R, MC4R and MC5R.
Positive_regulation (screened) of MC3R
1) Confidence 0.48 Published 2003 Journal Peptides Section Abstract Doc Link 12668212 Disease Relevance 0.22 Pain Relevance 0.18
Exciting new research shows that corticotropin acts peripherally by activation of the melanocortin type 3 receptor, and this could be responsible, at least in part, for its efficacy in acute gout.
Positive_regulation (activation) of melanocortin type 3 receptor associated with crystal associated disease
2) Confidence 0.05 Published 2008 Journal Drugs Section Abstract Doc Link 18318560 Disease Relevance 0.87 Pain Relevance 0.51

General Comments

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