INT109594

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.19
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABL1) protein modification process (ABL1) mitochondrion (ABL1)
nucleolus (ABL1) nucleus (ABL1) DNA binding (ABL1)
Anatomy Link Frequency
hepatocytes 1
proximal 1
lung 1
ABL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 7 93.92 High High
Spinal cord 3 44.00 Quite Low
abdominal pain 2 41.12 Quite Low
Pain 7 40.40 Quite Low
imagery 7 36.60 Quite Low
Analgesic 1 25.00 Low Low
Paracetamol 1 25.00 Low Low
cryotherapy 3 5.00 Very Low Very Low Very Low
Paresthesia 3 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 10 99.80 Very High Very High Very High
Myeloid Leukemia 15 99.74 Very High Very High Very High
Chronic Myeloid Leukemia 1 99.10 Very High Very High Very High
Cancer 20 98.92 Very High Very High Very High
Lung Cancer 1 98.04 Very High Very High Very High
Gastrointestinal Stromal Tumor 39 98.00 Very High Very High Very High
Non-small-cell Lung Cancer 4 97.08 Very High Very High Very High
Disease 52 94.08 High High
Disorder Of Lipid Metabolism 9 93.44 High High
Familial Dysautonomia 121 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the chronic phase, interferon alfa-2 is more effective than cytotoxic chemotherapies but it also has more adverse effects. (2) Imatinib inhibits tyrosine kinase, an enzyme encoded by the pathological gene BCR-ABL, which is created during a reverse translocation between chromosomes 9 and 22 (characteristic of chronic myeloid leukaemia).
Positive_regulation (created) of ABL associated with leukemia
1) Confidence 0.49 Published 2003 Journal Prescrire Int Section Abstract Doc Link 12669727 Disease Relevance 0.49 Pain Relevance 0
Imatinib, a receptor tyrosine kinase inhibitor, was first used in the treatment of chronic myelogenous leukemia, which is characterized by the constitutive activation of the Bcr-Abl tyrosine kinase [5].
Positive_regulation (activation) of Abl associated with chronic myeloid leukemia
2) Confidence 0.45 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2661077 Disease Relevance 0.59 Pain Relevance 0
Deregulated activation of protein tyrosine kinases, such as the epidermal growth factor receptor (EGFR) and Abl, is associated with human cancers including non-small cell lung cancer (NSCLC) and chronic myeloid leukemia (CML).
Positive_regulation (activation) of Abl in lung associated with leukemia, myeloid leukemia, lung cancer, non-small-cell lung cancer and cancer
3) Confidence 0.40 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20026060 Disease Relevance 0.95 Pain Relevance 0
In 1986, the APOB gene, its mRNA and the apo B content of the hepatocytes were found to be normal in ABL patients, suggesting that defective post-translational processing and secretion of apo B was the cause of ABL [3].
Positive_regulation (normal) of ABL in hepatocytes
4) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.71 Pain Relevance 0
Muller and co-workers [15] first reported in 1974 that high dose oral vitamin E (100 IU/kg) could increase undetectable serum vitamin levels in ABL patients.
Positive_regulation (increase) of ABL
5) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.74 Pain Relevance 0
In 1992, a deficiency of microsomal triglyceride transfer protein (MTP) activity was suggested to be the proximal cause of ABL [4].
Positive_regulation (cause) of ABL in proximal
6) Confidence 0.33 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.63 Pain Relevance 0
Since gene expression quantification using RT-qPCR requires a steady reference gene, we selected three genes frequently used for normalization of the data, ABL1, RPLP0, and HPRT1.
Positive_regulation (used) of ABL1
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.52 Pain Relevance 0
This oral drug is also active in all phases of chronic myeloid leukemia (CML) as it also targets the bcr-abl tyrosine kinase.
Positive_regulation (targets) of bcr-abl associated with leukemia and myeloid leukemia
8) Confidence 0.26 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.94 Pain Relevance 0.05
Targeting constitutively activated tyrosine kinases, such as BCR-ABL, in chronic myeloid leukaemia (CML) and c-KIT in gastrointestinal stromal tumours (GIST) has substantially changed the clinical management of both diseases.
Positive_regulation (Targeting) of BCR-ABL associated with leukemia, myeloid leukemia, disease and gastrointestinal stromal tumor
9) Confidence 0.12 Published 2009 Journal Drug Saf Section Abstract Doc Link 19810774 Disease Relevance 0.81 Pain Relevance 0
Targeting constitutively activated tyrosine kinases, such as BCR-ABL, in chronic myeloid leukaemia (CML) and c-KIT in gastrointestinal stromal tumours (GIST) has substantially changed the clinical management of both diseases.
Positive_regulation (activated) of BCR-ABL associated with leukemia, myeloid leukemia, disease and gastrointestinal stromal tumor
10) Confidence 0.12 Published 2009 Journal Drug Saf Section Abstract Doc Link 19810774 Disease Relevance 0.81 Pain Relevance 0

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